NRF2 Plays a Critical Role in Both Self and EGCG Protection against Diabetic Testicular Damage
Joint Authors
Wang, Fuchun
Li, Tie
Wu, Junduo
Song, Yanyan
Pan, Chenyu
Zhou, Shengzhu
Liu, Lingyun
Ha, Lijuan
Liu, Xiaona
Tian, Jingyan
Wu, Hao
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Activation of nuclear factor erythroid 2-related factor 2 (NRF2) has been found to ameliorate diabetic testicular damage (DTD) in rodents.
However, it was unclear whether NRF2 is required for these approaches in DTD.
Epigallocatechin gallate (EGCG) is a potent activator of NRF2 and has shown beneficial effects on multiple diabetic complications.
However, the effect of EGCG has not been studied in DTD.
The present study aims to explore the role of NRF2 in both self and EGCG protection against DTD.
Therefore, streptozotocin-induced diabetic C57BL/6 wild type (WT) and Nrf2 knockout (KO) mice were treated in the presence or absence of EGCG, for 24 weeks.
The Nrf2 KO mice exhibited more significant diabetes-induced loss in testicular weight and spermatozoa count, and increase in testicular apoptotic cell death, as compared with the WT mice.
EGCG activated NRF2 expression and function, preserved testicular weight and spermatozoa count, and attenuated testicular apoptotic cell death, endoplasmic reticulum stress, inflammation, and oxidative damage in the WT diabetic mice, but not the Nrf2 KO diabetic mice.
The present study demonstrated for the first time that NRF2 plays a critical role in both self and EGCG protection against DTD.
American Psychological Association (APA)
Pan, Chenyu& Zhou, Shengzhu& Wu, Junduo& Liu, Lingyun& Song, Yanyan& Li, Tie…[et al.]. 2017. NRF2 Plays a Critical Role in Both Self and EGCG Protection against Diabetic Testicular Damage. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1194258
Modern Language Association (MLA)
Pan, Chenyu…[et al.]. NRF2 Plays a Critical Role in Both Self and EGCG Protection against Diabetic Testicular Damage. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1194258
American Medical Association (AMA)
Pan, Chenyu& Zhou, Shengzhu& Wu, Junduo& Liu, Lingyun& Song, Yanyan& Li, Tie…[et al.]. NRF2 Plays a Critical Role in Both Self and EGCG Protection against Diabetic Testicular Damage. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1194258
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194258