Protective Effect of Antioxidants on Neuronal Dysfunction and Plasticity in Huntington’s Disease
المؤلفون المشاركون
Essa, Musthafa Mohamed
Jain, Sanjeev
Velusamy, Thirunavukkarasu
Panneerselvam, Archana S.
Anusuyadevi, Muthuswamy
Pal, Pramod Kumar
Kandasamy, Mahesh
Purushottam, Meera
Guillemin, Gilles J.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-12
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Huntington’s disease (HD) is characterised by movement disorders, cognitive impairments, and psychiatric problems.
The abnormal generation of reactive oxygen species and the resulting oxidative stress-induced mitochondrial damage in neurons upon CAG mutations in the HTT gene have been hypothesized as the contributing factors of neurodegeneration in HD.
The potential use of antioxidants against free radical toxicity has been an emerging field in the management of ageing and many neurodegenerative disorders.
Neural stem cells derived adult neurogenesis represents the regenerative capacity of the adult brain.
The process of adult neurogenesis has been implicated in the cognitive functions of the brain and is highly modulated positively by different factors including antioxidants.
The supportive role of antioxidants to reduce the severity of HD via promoting the functional neurogenesis and neuroprotection in the pathological adult brain has great promise.
This review comprehends the recent studies describing the therapeutic roles of antioxidants in HD and other neurologic disorders and highlights the scope of using antioxidants to promote adult neurogenesis in HD.
It also advocates a new line of research to delineate the mechanisms by which antioxidants promote adult neurogenesis in HD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Velusamy, Thirunavukkarasu& Panneerselvam, Archana S.& Purushottam, Meera& Anusuyadevi, Muthuswamy& Pal, Pramod Kumar& Jain, Sanjeev…[et al.]. 2017. Protective Effect of Antioxidants on Neuronal Dysfunction and Plasticity in Huntington’s Disease. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1194299
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Velusamy, Thirunavukkarasu…[et al.]. Protective Effect of Antioxidants on Neuronal Dysfunction and Plasticity in Huntington’s Disease. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1194299
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Velusamy, Thirunavukkarasu& Panneerselvam, Archana S.& Purushottam, Meera& Anusuyadevi, Muthuswamy& Pal, Pramod Kumar& Jain, Sanjeev…[et al.]. Protective Effect of Antioxidants on Neuronal Dysfunction and Plasticity in Huntington’s Disease. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1194299
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194299
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر