Protective Effect of Antioxidants on Neuronal Dysfunction and Plasticity in Huntington’s Disease
Joint Authors
Essa, Musthafa Mohamed
Jain, Sanjeev
Velusamy, Thirunavukkarasu
Panneerselvam, Archana S.
Anusuyadevi, Muthuswamy
Pal, Pramod Kumar
Kandasamy, Mahesh
Purushottam, Meera
Guillemin, Gilles J.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-12
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Huntington’s disease (HD) is characterised by movement disorders, cognitive impairments, and psychiatric problems.
The abnormal generation of reactive oxygen species and the resulting oxidative stress-induced mitochondrial damage in neurons upon CAG mutations in the HTT gene have been hypothesized as the contributing factors of neurodegeneration in HD.
The potential use of antioxidants against free radical toxicity has been an emerging field in the management of ageing and many neurodegenerative disorders.
Neural stem cells derived adult neurogenesis represents the regenerative capacity of the adult brain.
The process of adult neurogenesis has been implicated in the cognitive functions of the brain and is highly modulated positively by different factors including antioxidants.
The supportive role of antioxidants to reduce the severity of HD via promoting the functional neurogenesis and neuroprotection in the pathological adult brain has great promise.
This review comprehends the recent studies describing the therapeutic roles of antioxidants in HD and other neurologic disorders and highlights the scope of using antioxidants to promote adult neurogenesis in HD.
It also advocates a new line of research to delineate the mechanisms by which antioxidants promote adult neurogenesis in HD.
American Psychological Association (APA)
Velusamy, Thirunavukkarasu& Panneerselvam, Archana S.& Purushottam, Meera& Anusuyadevi, Muthuswamy& Pal, Pramod Kumar& Jain, Sanjeev…[et al.]. 2017. Protective Effect of Antioxidants on Neuronal Dysfunction and Plasticity in Huntington’s Disease. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1194299
Modern Language Association (MLA)
Velusamy, Thirunavukkarasu…[et al.]. Protective Effect of Antioxidants on Neuronal Dysfunction and Plasticity in Huntington’s Disease. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1194299
American Medical Association (AMA)
Velusamy, Thirunavukkarasu& Panneerselvam, Archana S.& Purushottam, Meera& Anusuyadevi, Muthuswamy& Pal, Pramod Kumar& Jain, Sanjeev…[et al.]. Protective Effect of Antioxidants on Neuronal Dysfunction and Plasticity in Huntington’s Disease. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1194299
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194299