Inhibition of Caveolae Contributes to Propofol Preconditioning-Suppressed Microvesicles Release and Cell Injury by Hypoxia-Reoxygenation
المؤلفون المشاركون
Zhang, Liangqing
Feng, Du
Wang, Shuang
Deng, Fan
Cai, Shuyun
Xu, Riping
Wang, Jingjing
Hu, Zhe
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-19
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Endothelial microvesicles (EMVs), released after endothelial cell (EC) apoptosis or activation, may carry many adverse signals and propagate injury by intercellular transmission.
Caveolae are 50–100 nm cell surface plasma membrane invaginations involved in many pathophysiological processes.
Recent evidence has indicated EMVs and caveolae may have functional effects in cells undergoing H/R injury.
Propofol, a widely used anaesthetic, confers antioxidative stress capability in the same process.
But the connection between EMVs, H/R, and caveolae remains largely unclear.
Here, we found that H/R significantly increased the release of EMVs, the expression of CAV-1 (the structural protein responsible for maintaining the shape of caveolae), oxidative stress, and the mitochondrial damage, and all these changes were inhibited by propofol preconditioning.
Interestingly, the caveolae inhibitor Mβ-CD strengthened the protective effect of propofol preconditioning.
We further found that the release of EMVs is more significantly reduced under propofol preconditioning in the presence of the caveolae inhibitor Mβ-CD.
EMVs released from H/R-treated cells caused a substantially increased mitochondrial and cellular damage to normal HUVECs after 4 hours of coculture.
Thus, we conclude that inhibition of caveolae contributes to propofol preconditioning-suppressed microvesicles release and cell injury by H/R.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Deng, Fan& Wang, Shuang& Cai, Shuyun& Hu, Zhe& Xu, Riping& Wang, Jingjing…[et al.]. 2017. Inhibition of Caveolae Contributes to Propofol Preconditioning-Suppressed Microvesicles Release and Cell Injury by Hypoxia-Reoxygenation. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1194369
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Deng, Fan…[et al.]. Inhibition of Caveolae Contributes to Propofol Preconditioning-Suppressed Microvesicles Release and Cell Injury by Hypoxia-Reoxygenation. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1194369
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Deng, Fan& Wang, Shuang& Cai, Shuyun& Hu, Zhe& Xu, Riping& Wang, Jingjing…[et al.]. Inhibition of Caveolae Contributes to Propofol Preconditioning-Suppressed Microvesicles Release and Cell Injury by Hypoxia-Reoxygenation. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1194369
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194369
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر