MicroRNAs and Autophagy: Fine Players in the Control of Chondrocyte Homeostatic Activities in Osteoarthritis
المؤلفون المشاركون
D’Adamo, Stefania
Cetrullo, Silvia
Minguzzi, Manuela
Silvestri, Ylenia
Borzì, Rosa Maria
Flamigni, Flavio
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-21
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Osteoarthritis (OA) is a debilitating degenerative disease of the articular cartilage with a multifactorial etiology.
Aging, the main risk factor for OA development, is associated with a systemic oxidative and inflammatory phenotype.
Autophagy is a central housekeeping system that plays an antiaging role by supporting the clearance of senescence-associated alterations of macromolecules and organelles.
Autophagy deficiency has been related to OA pathogenesis because of the accumulation of cellular defects in chondrocytes.
Microribonucleic acids (microRNAs or miRs) are a well-established class of posttranscriptional modulators belonging to the family of noncoding RNAs that have been identified as key players in the regulation of cellular processes, such as autophagy, by targeting their own cognate mRNAs.
Here, we present a state-of-the-art literature review on the role of miRs and autophagy in the scenario of OA pathogenesis.
In addition, a comprehensive survey has been performed on the functional connections of the miR network and the autophagy pathway in OA by using “microRNA,” “autophagy,” and “osteoarthritis” as key words.
Discussion of available evidence sheds light on some aspects that need further investigation in order to reach a more comprehensive view of the potential of this topic in OA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
D’Adamo, Stefania& Cetrullo, Silvia& Minguzzi, Manuela& Silvestri, Ylenia& Borzì, Rosa Maria& Flamigni, Flavio. 2017. MicroRNAs and Autophagy: Fine Players in the Control of Chondrocyte Homeostatic Activities in Osteoarthritis. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1194418
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
D’Adamo, Stefania…[et al.]. MicroRNAs and Autophagy: Fine Players in the Control of Chondrocyte Homeostatic Activities in Osteoarthritis. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1194418
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
D’Adamo, Stefania& Cetrullo, Silvia& Minguzzi, Manuela& Silvestri, Ylenia& Borzì, Rosa Maria& Flamigni, Flavio. MicroRNAs and Autophagy: Fine Players in the Control of Chondrocyte Homeostatic Activities in Osteoarthritis. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1194418
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194418
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر