MicroRNAs and Autophagy: Fine Players in the Control of Chondrocyte Homeostatic Activities in Osteoarthritis
Joint Authors
D’Adamo, Stefania
Cetrullo, Silvia
Minguzzi, Manuela
Silvestri, Ylenia
Borzì, Rosa Maria
Flamigni, Flavio
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-21
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Osteoarthritis (OA) is a debilitating degenerative disease of the articular cartilage with a multifactorial etiology.
Aging, the main risk factor for OA development, is associated with a systemic oxidative and inflammatory phenotype.
Autophagy is a central housekeeping system that plays an antiaging role by supporting the clearance of senescence-associated alterations of macromolecules and organelles.
Autophagy deficiency has been related to OA pathogenesis because of the accumulation of cellular defects in chondrocytes.
Microribonucleic acids (microRNAs or miRs) are a well-established class of posttranscriptional modulators belonging to the family of noncoding RNAs that have been identified as key players in the regulation of cellular processes, such as autophagy, by targeting their own cognate mRNAs.
Here, we present a state-of-the-art literature review on the role of miRs and autophagy in the scenario of OA pathogenesis.
In addition, a comprehensive survey has been performed on the functional connections of the miR network and the autophagy pathway in OA by using “microRNA,” “autophagy,” and “osteoarthritis” as key words.
Discussion of available evidence sheds light on some aspects that need further investigation in order to reach a more comprehensive view of the potential of this topic in OA.
American Psychological Association (APA)
D’Adamo, Stefania& Cetrullo, Silvia& Minguzzi, Manuela& Silvestri, Ylenia& Borzì, Rosa Maria& Flamigni, Flavio. 2017. MicroRNAs and Autophagy: Fine Players in the Control of Chondrocyte Homeostatic Activities in Osteoarthritis. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1194418
Modern Language Association (MLA)
D’Adamo, Stefania…[et al.]. MicroRNAs and Autophagy: Fine Players in the Control of Chondrocyte Homeostatic Activities in Osteoarthritis. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1194418
American Medical Association (AMA)
D’Adamo, Stefania& Cetrullo, Silvia& Minguzzi, Manuela& Silvestri, Ylenia& Borzì, Rosa Maria& Flamigni, Flavio. MicroRNAs and Autophagy: Fine Players in the Control of Chondrocyte Homeostatic Activities in Osteoarthritis. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1194418
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194418