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Expression and Role of the Calcium-Sensing Receptor in Rat Peripheral Blood Polymorphonuclear Neutrophils
المؤلفون المشاركون
Sun, Yihua
Zhai, Tai-yu
Cui, Bao-hong
Zou, Lei
Zeng, Jing-ya
Gao, Song
Zhao, Qianyu
Wang, Yuan
Xie, Wan-lin
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-10
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The calcium-sensing receptors (CaSRs) play an important role in many tissues and organs that are involved in inflammatory reactions.
Peripheral blood polymorphonuclear neutrophils (PMNs) are important inflammatory cells.
However, the expression and functions of CaSR in peripheral blood PMNs are still not reported.
In this study, we collected rat peripheral blood PMNs to observe the relationship between CaSR and PMNs.
From the results, we found first that the CaSR protein was expressed in PMNs, and it increased after PMNs were activated with fMLP.
In addition, CaSR activator cincalcet promoted the expression of CaSR and P-p65 (NF-κB signaling pathway protein) and Bcl-xl (antiapoptosis protein), and it increased the secretion of interleukin-6 (IL-6) and myeloperoxidase (MPO); meanwhile, it decreased proapoptosis protein Bax expression and the production of IL-10 and reactive oxygen species (ROS).
At the same time, cincalcet also decreased the PMN apoptosis rate analyzed by flow cytometry.
However, CaSR inhibitor NPS-2143 and NF-κB signaling pathway inhibitor PDTC reverse the results cited earlier.
All of these results indicated that CaSR can regulate PMN functions and status to play a role in inflammation, which is probably through the NF-κB signaling pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhai, Tai-yu& Cui, Bao-hong& Zou, Lei& Zeng, Jing-ya& Gao, Song& Zhao, Qianyu…[et al.]. 2017. Expression and Role of the Calcium-Sensing Receptor in Rat Peripheral Blood Polymorphonuclear Neutrophils. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1194471
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhai, Tai-yu…[et al.]. Expression and Role of the Calcium-Sensing Receptor in Rat Peripheral Blood Polymorphonuclear Neutrophils. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1194471
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhai, Tai-yu& Cui, Bao-hong& Zou, Lei& Zeng, Jing-ya& Gao, Song& Zhao, Qianyu…[et al.]. Expression and Role of the Calcium-Sensing Receptor in Rat Peripheral Blood Polymorphonuclear Neutrophils. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1194471
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194471
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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