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Autophagy Is a Protective Response to the Oxidative Damage to Endplate Chondrocytes in Intervertebral Disc: Implications for the Treatment of Degenerative Lumbar Disc
المؤلفون المشاركون
Chen, Ke
Lv, Xiaohua
Li, Wei
Yu, Fei
Lin, Jianjing
Ma, Junxuan
Xiao, Deming
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-22
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Low back pain (LBP) is the leading cause of disability in the elderly.
Intervertebral disc degeneration (IDD) was considered as the main cause for LBP.
Degeneration of cartilaginous endplate was a crucial harmful factor during the initiation and development of IDD.
Oxidative stress was implicated in IDD.
However, the underlying molecular mechanism for the degeneration of cartilaginous endplate remains elusive.
Herein, we found that oxidative stress could induce apoptosis and autophagy in endplate chondrocytes evidenced by western blot analysis, flow cytometry, immunofluorescence staining, GFP-LC3B transfection, and MDC staining.
In addition, we also found that the apoptosis of endplate chondrocytes was significantly increased after the inhibition of autophagy by bafilomycin A1 shown by flow cytometry.
Furthermore, mTOR pathway upstream autophagy was greatly suppressed suggested by western blot assay.
In conclusion, our study strongly revealed that oxidative stress could increase autophagy and apoptosis of endplate chondrocytes in intervertebral disc.
The increase of autophagy activity could prevent endplate chondrocytes from apoptosis.
The autophagy in endplate chondrocytes induced by oxidative stress was mTOR dependent.
These findings might shed some new lights on the mechanism for IDD and provide new strategies for the treatments of IDD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Ke& Lv, Xiaohua& Li, Wei& Yu, Fei& Lin, Jianjing& Ma, Junxuan…[et al.]. 2017. Autophagy Is a Protective Response to the Oxidative Damage to Endplate Chondrocytes in Intervertebral Disc: Implications for the Treatment of Degenerative Lumbar Disc. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1194527
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Ke…[et al.]. Autophagy Is a Protective Response to the Oxidative Damage to Endplate Chondrocytes in Intervertebral Disc: Implications for the Treatment of Degenerative Lumbar Disc. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1194527
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Ke& Lv, Xiaohua& Li, Wei& Yu, Fei& Lin, Jianjing& Ma, Junxuan…[et al.]. Autophagy Is a Protective Response to the Oxidative Damage to Endplate Chondrocytes in Intervertebral Disc: Implications for the Treatment of Degenerative Lumbar Disc. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1194527
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194527
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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