Reactive Oxygen Species Mediated Prostaglandin E2 Contributes to Acute Response of Epithelial Injury
المؤلفون المشاركون
Fu, Xiu-jun
Peng, Ying-Bo
Hu, Yi-Ping
Yao, Min
Zhang, Yi-Fan
Wang, Ying
Yu, Wei-Rong
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-09
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Reactive oxygen species (ROS) generated after tissue injury play a crucial role during wound healing through initiating acute inflammation, clarifying infection and dead tissue, and mediating various intracellular signal transduction.
Prostaglandin E2 (PGE2) has been identified as one of the major factors responsible for inflammation and tissue repair.
In this study, we tested our hypothesis that ROS produced by damaged human keratinocytes induces the synthesis of PGE2.
In vitro epithelial wounding model was used to observe the production of ROS and secretion of PGE2 as well as the involved signal pathway.
The mechanical injury caused the rapid production of ROS in in vitro cultured keratinocytes, which was significantly blocked by an inhibitor of nicotinamide adenine dinucleotide phosphate oxidase.
The increased intracellular ROS caused by mechanical injury stimulates PGE2 production in a time-dependent manner via the activation of cyclooxygenase-2 (COX-2), which was stimulated by phosphorylation of extracellular signal-regulated protein kinase (ERK).
These results indicate ROS-induced ERK activation leading to the activation of COX-2 and the synthesis of PGE2 in human keratinocytes responding to mechanical injury in the acute phase.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hu, Yi-Ping& Peng, Ying-Bo& Zhang, Yi-Fan& Wang, Ying& Yu, Wei-Rong& Yao, Min…[et al.]. 2017. Reactive Oxygen Species Mediated Prostaglandin E2 Contributes to Acute Response of Epithelial Injury. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1194571
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hu, Yi-Ping…[et al.]. Reactive Oxygen Species Mediated Prostaglandin E2 Contributes to Acute Response of Epithelial Injury. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1194571
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hu, Yi-Ping& Peng, Ying-Bo& Zhang, Yi-Fan& Wang, Ying& Yu, Wei-Rong& Yao, Min…[et al.]. Reactive Oxygen Species Mediated Prostaglandin E2 Contributes to Acute Response of Epithelial Injury. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1194571
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194571
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر