Biotransformation of Dioscorea nipponica by Rat Intestinal Microflora and Cardioprotective Effects of Diosgenin

المؤلفون المشاركون

Xiao, Zhangang
Feng, Jia-Fu
Tang, Yi-Na
Ji, Hong
Zhu, Lin
Yi, Tao

المصدر

Oxidative Medicine and Cellular Longevity

العدد

المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2017-09-20

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الأحياء

الملخص EN

Studying the biotransformation of natural products by intestinal microflora is an important approach to understanding how and why some medicines—particularly natural medicines—work.

In many cases, the active components are generated by metabolic activation.

This is critical for drug research and development.

As a means to explore the therapeutic mechanism of Dioscorea nipponica (DN), a medicinal plant used to treat myocardial ischemia (MI), metabolites generated by intestinal microflora from DN were identified, and the cardioprotective efficacy of these metabolites was evaluated.

Our results demonstrate that diosgenin is the main metabolite produced by rat intestinal microflora from DN.

Further, our results show that diosgenin protects the myocardium against ischemic insult through increasing enzymatic and nonenzymatic antioxidant levels in vivo and by decreasing oxidative stress damage.

These mechanisms explain the clinical efficacy of DN as an anti-MI drug.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Feng, Jia-Fu& Tang, Yi-Na& Ji, Hong& Xiao, Zhangang& Zhu, Lin& Yi, Tao. 2017. Biotransformation of Dioscorea nipponica by Rat Intestinal Microflora and Cardioprotective Effects of Diosgenin. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1194634

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Feng, Jia-Fu…[et al.]. Biotransformation of Dioscorea nipponica by Rat Intestinal Microflora and Cardioprotective Effects of Diosgenin. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1194634

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Feng, Jia-Fu& Tang, Yi-Na& Ji, Hong& Xiao, Zhangang& Zhu, Lin& Yi, Tao. Biotransformation of Dioscorea nipponica by Rat Intestinal Microflora and Cardioprotective Effects of Diosgenin. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1194634

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1194634