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Biotransformation of Dioscorea nipponica by Rat Intestinal Microflora and Cardioprotective Effects of Diosgenin
Joint Authors
Xiao, Zhangang
Feng, Jia-Fu
Tang, Yi-Na
Ji, Hong
Zhu, Lin
Yi, Tao
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Studying the biotransformation of natural products by intestinal microflora is an important approach to understanding how and why some medicines—particularly natural medicines—work.
In many cases, the active components are generated by metabolic activation.
This is critical for drug research and development.
As a means to explore the therapeutic mechanism of Dioscorea nipponica (DN), a medicinal plant used to treat myocardial ischemia (MI), metabolites generated by intestinal microflora from DN were identified, and the cardioprotective efficacy of these metabolites was evaluated.
Our results demonstrate that diosgenin is the main metabolite produced by rat intestinal microflora from DN.
Further, our results show that diosgenin protects the myocardium against ischemic insult through increasing enzymatic and nonenzymatic antioxidant levels in vivo and by decreasing oxidative stress damage.
These mechanisms explain the clinical efficacy of DN as an anti-MI drug.
American Psychological Association (APA)
Feng, Jia-Fu& Tang, Yi-Na& Ji, Hong& Xiao, Zhangang& Zhu, Lin& Yi, Tao. 2017. Biotransformation of Dioscorea nipponica by Rat Intestinal Microflora and Cardioprotective Effects of Diosgenin. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1194634
Modern Language Association (MLA)
Feng, Jia-Fu…[et al.]. Biotransformation of Dioscorea nipponica by Rat Intestinal Microflora and Cardioprotective Effects of Diosgenin. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1194634
American Medical Association (AMA)
Feng, Jia-Fu& Tang, Yi-Na& Ji, Hong& Xiao, Zhangang& Zhu, Lin& Yi, Tao. Biotransformation of Dioscorea nipponica by Rat Intestinal Microflora and Cardioprotective Effects of Diosgenin. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1194634
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194634