Toxicity and Immunogenicity in Murine Melanoma following Exposure to Physical Plasma-Derived Oxidants
المؤلفون المشاركون
Wende, Kristian
Weltmann, Klaus-Dieter
Bekeschus, Sander
Schmidt, Anke
Rödder, Katrin
Fregin, Bob
Otto, Oliver
Lippert, Maxi
Gandhirajan, Rajesh Kumar
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-27
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Metastatic melanoma is an aggressive and deadly disease.
Therapeutic advance has been achieved by antitumor chemo- and radiotherapy.
These modalities involve the generation of reactive oxygen and nitrogen species, affecting cellular viability, migration, and immunogenicity.
Such species are also created by cold physical plasma, an ionized gas capable of redox modulating cells and tissues without thermal damage.
Cold plasma has been suggested for anticancer therapy.
Here, melanoma cell toxicity, motility, and immunogenicity of murine metastatic melanoma cells were investigated following plasma exposure in vitro.
Cells were oxidized by plasma, leading to decreased metabolic activity and cell death.
Moreover, plasma decelerated melanoma cell growth, viability, and cell cycling.
This was accompanied by increased cellular stiffness and upregulation of zonula occludens 1 protein in the cell membrane.
Importantly, expression levels of immunogenic cell surface molecules such as major histocompatibility complex I, calreticulin, and melanocortin receptor 1 were significantly increased in response to plasma.
Finally, plasma treatment significantly decreased the release of vascular endothelial growth factor, a molecule with importance in angiogenesis.
Altogether, these results suggest beneficial toxicity of cold plasma in murine melanomas with a concomitant immunogenicity of potential interest in oncology.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bekeschus, Sander& Rödder, Katrin& Fregin, Bob& Otto, Oliver& Lippert, Maxi& Weltmann, Klaus-Dieter…[et al.]. 2017. Toxicity and Immunogenicity in Murine Melanoma following Exposure to Physical Plasma-Derived Oxidants. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194713
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bekeschus, Sander…[et al.]. Toxicity and Immunogenicity in Murine Melanoma following Exposure to Physical Plasma-Derived Oxidants. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1194713
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bekeschus, Sander& Rödder, Katrin& Fregin, Bob& Otto, Oliver& Lippert, Maxi& Weltmann, Klaus-Dieter…[et al.]. Toxicity and Immunogenicity in Murine Melanoma following Exposure to Physical Plasma-Derived Oxidants. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194713
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194713
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر