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Toxicity and Immunogenicity in Murine Melanoma following Exposure to Physical Plasma-Derived Oxidants
Joint Authors
Wende, Kristian
Weltmann, Klaus-Dieter
Bekeschus, Sander
Schmidt, Anke
Rödder, Katrin
Fregin, Bob
Otto, Oliver
Lippert, Maxi
Gandhirajan, Rajesh Kumar
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-27
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Metastatic melanoma is an aggressive and deadly disease.
Therapeutic advance has been achieved by antitumor chemo- and radiotherapy.
These modalities involve the generation of reactive oxygen and nitrogen species, affecting cellular viability, migration, and immunogenicity.
Such species are also created by cold physical plasma, an ionized gas capable of redox modulating cells and tissues without thermal damage.
Cold plasma has been suggested for anticancer therapy.
Here, melanoma cell toxicity, motility, and immunogenicity of murine metastatic melanoma cells were investigated following plasma exposure in vitro.
Cells were oxidized by plasma, leading to decreased metabolic activity and cell death.
Moreover, plasma decelerated melanoma cell growth, viability, and cell cycling.
This was accompanied by increased cellular stiffness and upregulation of zonula occludens 1 protein in the cell membrane.
Importantly, expression levels of immunogenic cell surface molecules such as major histocompatibility complex I, calreticulin, and melanocortin receptor 1 were significantly increased in response to plasma.
Finally, plasma treatment significantly decreased the release of vascular endothelial growth factor, a molecule with importance in angiogenesis.
Altogether, these results suggest beneficial toxicity of cold plasma in murine melanomas with a concomitant immunogenicity of potential interest in oncology.
American Psychological Association (APA)
Bekeschus, Sander& Rödder, Katrin& Fregin, Bob& Otto, Oliver& Lippert, Maxi& Weltmann, Klaus-Dieter…[et al.]. 2017. Toxicity and Immunogenicity in Murine Melanoma following Exposure to Physical Plasma-Derived Oxidants. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194713
Modern Language Association (MLA)
Bekeschus, Sander…[et al.]. Toxicity and Immunogenicity in Murine Melanoma following Exposure to Physical Plasma-Derived Oxidants. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1194713
American Medical Association (AMA)
Bekeschus, Sander& Rödder, Katrin& Fregin, Bob& Otto, Oliver& Lippert, Maxi& Weltmann, Klaus-Dieter…[et al.]. Toxicity and Immunogenicity in Murine Melanoma following Exposure to Physical Plasma-Derived Oxidants. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194713
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194713