Experimental and Clinical Applications of Chamaecyparis obtusa Extracts in Dry Eye Disease
المؤلفون المشاركون
Choi, Joo-Hee
Yoon, Kyung-Chul
Jeong, Jieun
Choi, Won
Cui, Lian
Li, Ying
Lee, Hyo Seok
Yun, Je-Jung
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-26
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Purpose.
To investigate the effects of Chamaecyparis obtusa (CO) on human corneal epithelial (HCE) cells, a murine experimental dry eye (EDE) model, and the efficacy of antioxidant eye mask in dry eye disease (DED) patients.
Methods.
0.001%, 0.01%, and 0.1% CO extracts were used to treat HCE cells, cell viability, and production of antioxidative enzymes, and reactive oxygen species (ROS) were assessed.
Afterwards, CO extracts or balanced salt solution (BSS) was applied in EDE.
Clinical and experimental parameters were measured at 7 days after treatment.
In addition, DED patients were randomly assigned to wear either an eye mask containing CO extracts or a placebo.
Clinical parameters were evaluated.
Results.
The viability of HCE cells and antioxidative enzyme expression significantly improved after treatment with 0.1% CO extracts.
Mice treated with 0.1% CO extracts showed significant improvement in clinical parameters.
During the trial, the clinical parameters significantly improved in the treatment group at 4 weeks after application.
Conclusions.
0.1% CO extracts could promote the expression of antioxidative proteins and ROS production.
In addition, an eye mask containing CO extracts could improve DED clinical parameters.
These suggest that CO extracts may be useful as an adjunctive option for the DED treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cui, Lian& Lee, Hyo Seok& Li, Ying& Choi, Joo-Hee& Yun, Je-Jung& Jeong, Jieun…[et al.]. 2017. Experimental and Clinical Applications of Chamaecyparis obtusa Extracts in Dry Eye Disease. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194731
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cui, Lian…[et al.]. Experimental and Clinical Applications of Chamaecyparis obtusa Extracts in Dry Eye Disease. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1194731
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cui, Lian& Lee, Hyo Seok& Li, Ying& Choi, Joo-Hee& Yun, Je-Jung& Jeong, Jieun…[et al.]. Experimental and Clinical Applications of Chamaecyparis obtusa Extracts in Dry Eye Disease. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194731
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194731
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر