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Experimental and Clinical Applications of Chamaecyparis obtusa Extracts in Dry Eye Disease
Joint Authors
Choi, Joo-Hee
Yoon, Kyung-Chul
Jeong, Jieun
Choi, Won
Cui, Lian
Li, Ying
Lee, Hyo Seok
Yun, Je-Jung
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Purpose.
To investigate the effects of Chamaecyparis obtusa (CO) on human corneal epithelial (HCE) cells, a murine experimental dry eye (EDE) model, and the efficacy of antioxidant eye mask in dry eye disease (DED) patients.
Methods.
0.001%, 0.01%, and 0.1% CO extracts were used to treat HCE cells, cell viability, and production of antioxidative enzymes, and reactive oxygen species (ROS) were assessed.
Afterwards, CO extracts or balanced salt solution (BSS) was applied in EDE.
Clinical and experimental parameters were measured at 7 days after treatment.
In addition, DED patients were randomly assigned to wear either an eye mask containing CO extracts or a placebo.
Clinical parameters were evaluated.
Results.
The viability of HCE cells and antioxidative enzyme expression significantly improved after treatment with 0.1% CO extracts.
Mice treated with 0.1% CO extracts showed significant improvement in clinical parameters.
During the trial, the clinical parameters significantly improved in the treatment group at 4 weeks after application.
Conclusions.
0.1% CO extracts could promote the expression of antioxidative proteins and ROS production.
In addition, an eye mask containing CO extracts could improve DED clinical parameters.
These suggest that CO extracts may be useful as an adjunctive option for the DED treatment.
American Psychological Association (APA)
Cui, Lian& Lee, Hyo Seok& Li, Ying& Choi, Joo-Hee& Yun, Je-Jung& Jeong, Jieun…[et al.]. 2017. Experimental and Clinical Applications of Chamaecyparis obtusa Extracts in Dry Eye Disease. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194731
Modern Language Association (MLA)
Cui, Lian…[et al.]. Experimental and Clinical Applications of Chamaecyparis obtusa Extracts in Dry Eye Disease. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1194731
American Medical Association (AMA)
Cui, Lian& Lee, Hyo Seok& Li, Ying& Choi, Joo-Hee& Yun, Je-Jung& Jeong, Jieun…[et al.]. Experimental and Clinical Applications of Chamaecyparis obtusa Extracts in Dry Eye Disease. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194731
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194731