NADPH Oxidase Deficiency: A Multisystem Approach
المؤلفون المشاركون
Pignata, Claudio
Loffredo, Lorenzo
Giardino, Giuliana
Cicalese, Maria Pia
Delmonte, Ottavia
Migliavacca, Maddalena
Palterer, Boaz
Cirillo, Emilia
Gallo, Vera
Violi, Francesco
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-23، 23ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-21
دولة النشر
مصر
عدد الصفحات
23
التخصصات الرئيسية
الملخص EN
The immune system is a complex system able to recognize a wide variety of host agents, through different biological processes.
For example, controlled changes in the redox state are able to start different pathways in immune cells and are involved in the killing of microbes.
The generation and release of ROS in the form of an “oxidative burst” represent the pivotal mechanism by which phagocytic cells are able to destroy pathogens.
On the other hand, impaired oxidative balance is also implicated in the pathogenesis of inflammatory complications, which may affect the function of many body systems.
NADPH oxidase (NOX) plays a pivotal role in the production of ROS, and the defect of its different subunits leads to the development of chronic granulomatous disease (CGD).
The defect of the different NOX subunits in CGD affects different organs.
In this context, this review will be focused on the description of the effect of NOX2 deficiency in different body systems.
Moreover, we will also focus our attention on the novel insight in the pathogenesis of immunodeficiency and inflammation-related manifestations and on the protective role of NOX2 deficiency against the development of atherosclerosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Giardino, Giuliana& Cicalese, Maria Pia& Delmonte, Ottavia& Migliavacca, Maddalena& Palterer, Boaz& Loffredo, Lorenzo…[et al.]. 2017. NADPH Oxidase Deficiency: A Multisystem Approach. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-23.
https://search.emarefa.net/detail/BIM-1194751
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Giardino, Giuliana…[et al.]. NADPH Oxidase Deficiency: A Multisystem Approach. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-23.
https://search.emarefa.net/detail/BIM-1194751
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Giardino, Giuliana& Cicalese, Maria Pia& Delmonte, Ottavia& Migliavacca, Maddalena& Palterer, Boaz& Loffredo, Lorenzo…[et al.]. NADPH Oxidase Deficiency: A Multisystem Approach. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-23.
https://search.emarefa.net/detail/BIM-1194751
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194751
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر