![](/images/graphics-bg.png)
NADPH Oxidase Deficiency: A Multisystem Approach
Joint Authors
Pignata, Claudio
Loffredo, Lorenzo
Giardino, Giuliana
Cicalese, Maria Pia
Delmonte, Ottavia
Migliavacca, Maddalena
Palterer, Boaz
Cirillo, Emilia
Gallo, Vera
Violi, Francesco
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-21
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
The immune system is a complex system able to recognize a wide variety of host agents, through different biological processes.
For example, controlled changes in the redox state are able to start different pathways in immune cells and are involved in the killing of microbes.
The generation and release of ROS in the form of an “oxidative burst” represent the pivotal mechanism by which phagocytic cells are able to destroy pathogens.
On the other hand, impaired oxidative balance is also implicated in the pathogenesis of inflammatory complications, which may affect the function of many body systems.
NADPH oxidase (NOX) plays a pivotal role in the production of ROS, and the defect of its different subunits leads to the development of chronic granulomatous disease (CGD).
The defect of the different NOX subunits in CGD affects different organs.
In this context, this review will be focused on the description of the effect of NOX2 deficiency in different body systems.
Moreover, we will also focus our attention on the novel insight in the pathogenesis of immunodeficiency and inflammation-related manifestations and on the protective role of NOX2 deficiency against the development of atherosclerosis.
American Psychological Association (APA)
Giardino, Giuliana& Cicalese, Maria Pia& Delmonte, Ottavia& Migliavacca, Maddalena& Palterer, Boaz& Loffredo, Lorenzo…[et al.]. 2017. NADPH Oxidase Deficiency: A Multisystem Approach. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-23.
https://search.emarefa.net/detail/BIM-1194751
Modern Language Association (MLA)
Giardino, Giuliana…[et al.]. NADPH Oxidase Deficiency: A Multisystem Approach. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-23.
https://search.emarefa.net/detail/BIM-1194751
American Medical Association (AMA)
Giardino, Giuliana& Cicalese, Maria Pia& Delmonte, Ottavia& Migliavacca, Maddalena& Palterer, Boaz& Loffredo, Lorenzo…[et al.]. NADPH Oxidase Deficiency: A Multisystem Approach. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-23.
https://search.emarefa.net/detail/BIM-1194751
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194751