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Tualang Honey Protects the Rat Midbrain and Lung against Repeated Paraquat Exposure
المؤلفون المشاركون
Jaafar, Hasnan
Sulaiman, Siti Amrah
Muzaimi, Mustapha
Tang, Suk Peng
Sirajudeen, Kuttulebbai N. S.
Gan, Siew Hua
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-03
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Paraquat (PQ) is a dopaminergic neurotoxin and a well-known pneumotoxicant that exerts its toxic effect via oxidative stress-mediated cellular injuries.
This study investigated the protective effects of Tualang honey against PQ-induced toxicity in the midbrain and lungs of rats.
The rats were orally treated with distilled water (2 mL/kg/day), Tualang honey (1.0 g/kg/day), or ubiquinol (0.2 g/kg/day) throughout the experimental period.
Two weeks after the respective treatments, the rats were injected intraperitoneally with saline (1 mL/kg/week) or PQ (10 mg/kg/week) once per week for four consecutive weeks.
After four weekly exposures to PQ, the glutathione peroxidase activity and the number of tyrosine-hydroxylase immunopositive neurons in the midbrain were significantly decreased in animals from group PQ (p<0.05).
The lungs of animals from group PQ showed significantly decreased activity of superoxide dismutase and glutathione-S-transferase.
Treatment with Tualang honey ameliorated the toxic effects observed in the midbrain and lungs.
The beneficial effects of Tualang honey were comparable to those of ubiquinol, which was used as a positive control.
These findings suggest that treatment with Tualang honey may protect against PQ-induced toxicity in the rat midbrain and lung.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tang, Suk Peng& Sirajudeen, Kuttulebbai N. S.& Jaafar, Hasnan& Gan, Siew Hua& Muzaimi, Mustapha& Sulaiman, Siti Amrah. 2017. Tualang Honey Protects the Rat Midbrain and Lung against Repeated Paraquat Exposure. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194761
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tang, Suk Peng…[et al.]. Tualang Honey Protects the Rat Midbrain and Lung against Repeated Paraquat Exposure. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1194761
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tang, Suk Peng& Sirajudeen, Kuttulebbai N. S.& Jaafar, Hasnan& Gan, Siew Hua& Muzaimi, Mustapha& Sulaiman, Siti Amrah. Tualang Honey Protects the Rat Midbrain and Lung against Repeated Paraquat Exposure. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194761
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194761
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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