Tualang Honey Protects the Rat Midbrain and Lung against Repeated Paraquat Exposure
Joint Authors
Jaafar, Hasnan
Sulaiman, Siti Amrah
Muzaimi, Mustapha
Tang, Suk Peng
Sirajudeen, Kuttulebbai N. S.
Gan, Siew Hua
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Paraquat (PQ) is a dopaminergic neurotoxin and a well-known pneumotoxicant that exerts its toxic effect via oxidative stress-mediated cellular injuries.
This study investigated the protective effects of Tualang honey against PQ-induced toxicity in the midbrain and lungs of rats.
The rats were orally treated with distilled water (2 mL/kg/day), Tualang honey (1.0 g/kg/day), or ubiquinol (0.2 g/kg/day) throughout the experimental period.
Two weeks after the respective treatments, the rats were injected intraperitoneally with saline (1 mL/kg/week) or PQ (10 mg/kg/week) once per week for four consecutive weeks.
After four weekly exposures to PQ, the glutathione peroxidase activity and the number of tyrosine-hydroxylase immunopositive neurons in the midbrain were significantly decreased in animals from group PQ (p<0.05).
The lungs of animals from group PQ showed significantly decreased activity of superoxide dismutase and glutathione-S-transferase.
Treatment with Tualang honey ameliorated the toxic effects observed in the midbrain and lungs.
The beneficial effects of Tualang honey were comparable to those of ubiquinol, which was used as a positive control.
These findings suggest that treatment with Tualang honey may protect against PQ-induced toxicity in the rat midbrain and lung.
American Psychological Association (APA)
Tang, Suk Peng& Sirajudeen, Kuttulebbai N. S.& Jaafar, Hasnan& Gan, Siew Hua& Muzaimi, Mustapha& Sulaiman, Siti Amrah. 2017. Tualang Honey Protects the Rat Midbrain and Lung against Repeated Paraquat Exposure. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194761
Modern Language Association (MLA)
Tang, Suk Peng…[et al.]. Tualang Honey Protects the Rat Midbrain and Lung against Repeated Paraquat Exposure. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1194761
American Medical Association (AMA)
Tang, Suk Peng& Sirajudeen, Kuttulebbai N. S.& Jaafar, Hasnan& Gan, Siew Hua& Muzaimi, Mustapha& Sulaiman, Siti Amrah. Tualang Honey Protects the Rat Midbrain and Lung against Repeated Paraquat Exposure. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194761
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194761