Multifaceted Roles of GSK-3 in Cancer and Autophagy-Related Diseases
المؤلفون المشاركون
Petrungaro, Simonetta
Facchiano, Antonio
Mancinelli, Romina
Mammola, Caterina Loredana
Tomaipitinca, Luana
Ziparo, Elio
Filippini, Antonio
Carpino, Guido
Giampietri, Claudia
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-12
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
GSK-3 is a ubiquitously expressed serine/threonine kinase existing as GSK-3α and GSK-3β isoforms, both active under basal conditions and inactivated upon phosphorylation by different upstream kinases.
Initially discovered as a regulator of glycogen synthesis, GSK-3 is also involved in several signaling pathways controlling many different key functions.
Here, we discuss recent advances regarding (i) GSK-3 structure, function, regulation, and involvement in several cancers, including hepatocarcinoma, cholangiocarcinoma, breast cancer, prostate cancer, leukemia, and melanoma (active GSK-3 has been shown to induce apoptosis in some cases or inhibit apoptosis in other cases and to induce cancer progression or inhibit tumor cell proliferation, suggesting that different GSK-3 modulators may address different specific targets); (ii) GSK-3 involvement in autophagy modulation, reviewing signaling pathways involved in neurodegenerative and liver diseases; (iii) GSK-3 role in oxidative stress and autophagic cell death, focusing on liver injury; (iv) GSK-3 as a possible therapeutic target of natural substances and synthetic inhibitors in many diseases; and (v) GSK-3 role as modulator of mammalian aging, related to metabolic alterations characterizing senescent cells and age-related diseases.
Studies summarized here underline the GSK-3 multifaceted role and indicate such kinase as a molecular target in different pathologies, including diseases associated with autophagy dysregulation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mancinelli, Romina& Carpino, Guido& Petrungaro, Simonetta& Mammola, Caterina Loredana& Tomaipitinca, Luana& Filippini, Antonio…[et al.]. 2017. Multifaceted Roles of GSK-3 in Cancer and Autophagy-Related Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1194770
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mancinelli, Romina…[et al.]. Multifaceted Roles of GSK-3 in Cancer and Autophagy-Related Diseases. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1194770
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mancinelli, Romina& Carpino, Guido& Petrungaro, Simonetta& Mammola, Caterina Loredana& Tomaipitinca, Luana& Filippini, Antonio…[et al.]. Multifaceted Roles of GSK-3 in Cancer and Autophagy-Related Diseases. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1194770
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194770
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر