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Multifaceted Roles of GSK-3 in Cancer and Autophagy-Related Diseases
Joint Authors
Petrungaro, Simonetta
Facchiano, Antonio
Mancinelli, Romina
Mammola, Caterina Loredana
Tomaipitinca, Luana
Ziparo, Elio
Filippini, Antonio
Carpino, Guido
Giampietri, Claudia
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-12
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
GSK-3 is a ubiquitously expressed serine/threonine kinase existing as GSK-3α and GSK-3β isoforms, both active under basal conditions and inactivated upon phosphorylation by different upstream kinases.
Initially discovered as a regulator of glycogen synthesis, GSK-3 is also involved in several signaling pathways controlling many different key functions.
Here, we discuss recent advances regarding (i) GSK-3 structure, function, regulation, and involvement in several cancers, including hepatocarcinoma, cholangiocarcinoma, breast cancer, prostate cancer, leukemia, and melanoma (active GSK-3 has been shown to induce apoptosis in some cases or inhibit apoptosis in other cases and to induce cancer progression or inhibit tumor cell proliferation, suggesting that different GSK-3 modulators may address different specific targets); (ii) GSK-3 involvement in autophagy modulation, reviewing signaling pathways involved in neurodegenerative and liver diseases; (iii) GSK-3 role in oxidative stress and autophagic cell death, focusing on liver injury; (iv) GSK-3 as a possible therapeutic target of natural substances and synthetic inhibitors in many diseases; and (v) GSK-3 role as modulator of mammalian aging, related to metabolic alterations characterizing senescent cells and age-related diseases.
Studies summarized here underline the GSK-3 multifaceted role and indicate such kinase as a molecular target in different pathologies, including diseases associated with autophagy dysregulation.
American Psychological Association (APA)
Mancinelli, Romina& Carpino, Guido& Petrungaro, Simonetta& Mammola, Caterina Loredana& Tomaipitinca, Luana& Filippini, Antonio…[et al.]. 2017. Multifaceted Roles of GSK-3 in Cancer and Autophagy-Related Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1194770
Modern Language Association (MLA)
Mancinelli, Romina…[et al.]. Multifaceted Roles of GSK-3 in Cancer and Autophagy-Related Diseases. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1194770
American Medical Association (AMA)
Mancinelli, Romina& Carpino, Guido& Petrungaro, Simonetta& Mammola, Caterina Loredana& Tomaipitinca, Luana& Filippini, Antonio…[et al.]. Multifaceted Roles of GSK-3 in Cancer and Autophagy-Related Diseases. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1194770
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1194770