Effect of Weight Loss, Exercise, or Both on Undercarboxylated Osteocalcin and Insulin Secretion in Frail, Obese Older Adults
المؤلفون المشاركون
Napoli, Nicola
Villareal, Dennis T.
Armamento-Villareal, Reina
Colleluori, Georgia
Phadnis, Uma
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-23
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
Obesity exacerbates age-related decline in glucometabolic control.
Undercarboxylated osteocalcin (UcOC) regulates pancreatic insulin secretion.
The long-term effect of lifestyle interventions on UcOC and insulin secretion has not been investigated.
Methods.
One hundred seven frail, obese older adults were randomized into the control (N=27), diet (N=26), exercise (N=26), and diet-exercise (N=28) groups for 1 year.
Main outcomes included changes in UcOC and disposition index (DI).
Results.
UcOC increased in the diet group (36 ± 11.6%) but not in the other groups (P<0.05 between groups).
Although similar increases in DI occurred in the diet-exercise and diet groups at 6 months, DI increased more in the diet-exercise group (92.4 ± 11.4%) than in the diet group (61.9 ± 15.3%) at 12 months (P<0.05).
UcOC and body composition changes predicted DI variation in the diet group only (R2=0.712), while adipocytokines and physical function changes contributed to DI variation in both the diet (∆R2=0.140 and 0.107) and diet-exercise (∆R2=0.427 and 0.243) groups (P<0.05 for all).
Conclusions.
Diet, but not exercise or both, increases UcOC, whereas both diet and diet-exercise increase DI.
UcOC accounts for DI variation only during active weight loss, while adipocytokines and physical function contribute to diet-exercise-induced DI variation, highlighting different mechanisms for lifestyle-induced improvements in insulin secretion.
This trial was registered with ClinicalTrials.gov number NCT00146107.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Colleluori, Georgia& Napoli, Nicola& Phadnis, Uma& Armamento-Villareal, Reina& Villareal, Dennis T.. 2017. Effect of Weight Loss, Exercise, or Both on Undercarboxylated Osteocalcin and Insulin Secretion in Frail, Obese Older Adults. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194808
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Colleluori, Georgia…[et al.]. Effect of Weight Loss, Exercise, or Both on Undercarboxylated Osteocalcin and Insulin Secretion in Frail, Obese Older Adults. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1194808
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Colleluori, Georgia& Napoli, Nicola& Phadnis, Uma& Armamento-Villareal, Reina& Villareal, Dennis T.. Effect of Weight Loss, Exercise, or Both on Undercarboxylated Osteocalcin and Insulin Secretion in Frail, Obese Older Adults. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194808
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194808
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر