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Characterization of NO-Induced Nitrosative Status in Human Placenta from Pregnant Women with Gestational Diabetes Mellitus
المؤلفون المشاركون
Aguilar-Diosdado, Manuel
Segundo, Carmen
Mateos, Rosa María
Visiedo, Francisco
Santos-Rosendo, Celeste
Gil-Sánchez, M. del Mar
Bugatto, Fernando
López-Tinoco, Cristina
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-16
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Dysregulation of NO production is implicated in pregnancy-related diseases, including gestational diabetes mellitus (GDM).
The role of NO and its placental targets in GDM pregnancies has yet to be determined.
S-Nitrosylation is the NO-derived posttranslational protein modification that can modulate biological functions by forming NO-derived complexes with longer half-life, termed S-nitrosothiol (SNO).
Our aim was to examine the presence of endogenous S-nitrosylated proteins in cysteine residues in relation to antioxidant defense, apoptosis, and cellular signal transduction in placental tissue from control (n=8) and GDM (n=8) pregnancies.
S-Nitrosylation was measured using the biotin-switch assay, while the expression and protein activity were assessed by immunoblotting and colorimetric methods, respectively.
Results indicated that catalase and peroxiredoxin nitrosylation levels were greater in GDM placentas, and that was accompanied by reduced catalase activity.
S-Nitrosylation of ERK1/2 and AKT was increased in GDM placentas, and their activities were inhibited.
Activities of caspase-3 and caspase-9 were increased, with the latter also showing diminished nitrosylation levels.
These findings suggest that S-nitrosylation is a little-known, but critical, mechanism by which NO directly modulates key placental proteins in women with GDM and, as a consequence, maternal and fetal anomalies during pregnancy can occur.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Visiedo, Francisco& Santos-Rosendo, Celeste& Mateos, Rosa María& Gil-Sánchez, M. del Mar& Bugatto, Fernando& Aguilar-Diosdado, Manuel…[et al.]. 2017. Characterization of NO-Induced Nitrosative Status in Human Placenta from Pregnant Women with Gestational Diabetes Mellitus. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1194996
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Visiedo, Francisco…[et al.]. Characterization of NO-Induced Nitrosative Status in Human Placenta from Pregnant Women with Gestational Diabetes Mellitus. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1194996
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Visiedo, Francisco& Santos-Rosendo, Celeste& Mateos, Rosa María& Gil-Sánchez, M. del Mar& Bugatto, Fernando& Aguilar-Diosdado, Manuel…[et al.]. Characterization of NO-Induced Nitrosative Status in Human Placenta from Pregnant Women with Gestational Diabetes Mellitus. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1194996
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194996
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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