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Protein Posttranslational Modifications: Roles in Aging and Age-Related Disease
المؤلفون المشاركون
Santos, Ana L.
Lindner, Ariel B.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-15
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
Aging is characterized by the progressive decline of biochemical and physiological function in an individual.
Consequently, aging is a major risk factor for diseases like cancer, obesity, and type 2 diabetes.
The cellular and molecular mechanisms of aging are not well understood, nor is the relationship between aging and the onset of diseases.
One of the hallmarks of aging is a decrease in cellular proteome homeostasis, allowing abnormal proteins to accumulate.
This phenomenon is observed in both eukaryotes and prokaryotes, suggesting that the underlying molecular processes are evolutionarily conserved.
Similar protein aggregation occurs in the pathogenesis of diseases like Alzheimer’s and Parkinson’s.
Further, protein posttranslational modifications (PTMs), either spontaneous or physiological/pathological, are emerging as important markers of aging and aging-related diseases, though clear causality has not yet been firmly established.
This review presents an overview of the interplay of PTMs in aging-associated molecular processes in eukaryotic aging models.
Understanding PTM roles in aging could facilitate targeted therapies or interventions for age-related diseases.
In addition, the study of PTMs in prokaryotes is highlighted, revealing the potential of simple prokaryotic models to uncover complex aging-associated molecular processes in the emerging field of microbiogerontology.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Santos, Ana L.& Lindner, Ariel B.. 2017. Protein Posttranslational Modifications: Roles in Aging and Age-Related Disease. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-19.
https://search.emarefa.net/detail/BIM-1195028
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Santos, Ana L.& Lindner, Ariel B.. Protein Posttranslational Modifications: Roles in Aging and Age-Related Disease. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-19.
https://search.emarefa.net/detail/BIM-1195028
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Santos, Ana L.& Lindner, Ariel B.. Protein Posttranslational Modifications: Roles in Aging and Age-Related Disease. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-19.
https://search.emarefa.net/detail/BIM-1195028
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1195028
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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