Protein Posttranslational Modifications: Roles in Aging and Age-Related Disease
Joint Authors
Santos, Ana L.
Lindner, Ariel B.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-15
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Aging is characterized by the progressive decline of biochemical and physiological function in an individual.
Consequently, aging is a major risk factor for diseases like cancer, obesity, and type 2 diabetes.
The cellular and molecular mechanisms of aging are not well understood, nor is the relationship between aging and the onset of diseases.
One of the hallmarks of aging is a decrease in cellular proteome homeostasis, allowing abnormal proteins to accumulate.
This phenomenon is observed in both eukaryotes and prokaryotes, suggesting that the underlying molecular processes are evolutionarily conserved.
Similar protein aggregation occurs in the pathogenesis of diseases like Alzheimer’s and Parkinson’s.
Further, protein posttranslational modifications (PTMs), either spontaneous or physiological/pathological, are emerging as important markers of aging and aging-related diseases, though clear causality has not yet been firmly established.
This review presents an overview of the interplay of PTMs in aging-associated molecular processes in eukaryotic aging models.
Understanding PTM roles in aging could facilitate targeted therapies or interventions for age-related diseases.
In addition, the study of PTMs in prokaryotes is highlighted, revealing the potential of simple prokaryotic models to uncover complex aging-associated molecular processes in the emerging field of microbiogerontology.
American Psychological Association (APA)
Santos, Ana L.& Lindner, Ariel B.. 2017. Protein Posttranslational Modifications: Roles in Aging and Age-Related Disease. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-19.
https://search.emarefa.net/detail/BIM-1195028
Modern Language Association (MLA)
Santos, Ana L.& Lindner, Ariel B.. Protein Posttranslational Modifications: Roles in Aging and Age-Related Disease. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-19.
https://search.emarefa.net/detail/BIM-1195028
American Medical Association (AMA)
Santos, Ana L.& Lindner, Ariel B.. Protein Posttranslational Modifications: Roles in Aging and Age-Related Disease. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-19.
https://search.emarefa.net/detail/BIM-1195028
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195028