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Troxerutin Reduces Kidney Damage against BDE-47-Induced Apoptosis via Inhibiting NOX2 Activity and Increasing Nrf2 Activity
المؤلفون المشاركون
Lu, Jun
Shan, Qun
Zheng, Yuanlin
Zhuang, Juan
Zheng, Guihong
Zhang, Zifeng
Zhang, Yanqiu
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-15
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
2,2,4,4-Tetrabromodiphenyl ether (BDE-47), one of the persistent organic pollutants, seriously influences the quality of life; however, its pathological mechanism remains unclear.
Troxerutin is a flavonoid with pharmacological activity of antioxidation and anti-inflammation.
In the present study, we investigated troxerutin against BDE-47-induced kidney cell apoptosis and explored the underlying mechanism.
The results show that troxerutin reduced renal cell apoptosis and urinary protein secretion in BDE-47-treated mice.
Western blot analysis shows that troxerutin supplement enhanced the ratio of Bcl-2/Bax; inhibited the release of cytochrome c from mitochondria, the activation of procaspase-9 and procaspase-3, and the cleavage of PARP; and reduced FAS, FASL, and caspase-8 levels induced by BDE-47.
In addition, troxerutin decreased the production of reactive oxygen species (ROS) and increased the activities of antioxidative enzymes.
Furthermore, troxerutin blunted Nrf2 ubiquitylation, enhanced the activity of Nrf2, decreased the activity of NOX2, and ameliorated kidney oxidant status of BDE-47-treated mice.
Together, these results confirm that troxerutin could alleviate the cytotoxicity of BDE-47 through antioxidation and antiapoptosis, which suggests that its protective mechanism is involved in the inhibition of apoptosis via suppressing NOX2 activity and increasing Nrf2 signaling pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shan, Qun& Zhuang, Juan& Zheng, Guihong& Zhang, Zifeng& Zhang, Yanqiu& Lu, Jun…[et al.]. 2017. Troxerutin Reduces Kidney Damage against BDE-47-Induced Apoptosis via Inhibiting NOX2 Activity and Increasing Nrf2 Activity. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1195127
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shan, Qun…[et al.]. Troxerutin Reduces Kidney Damage against BDE-47-Induced Apoptosis via Inhibiting NOX2 Activity and Increasing Nrf2 Activity. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1195127
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shan, Qun& Zhuang, Juan& Zheng, Guihong& Zhang, Zifeng& Zhang, Yanqiu& Lu, Jun…[et al.]. Troxerutin Reduces Kidney Damage against BDE-47-Induced Apoptosis via Inhibiting NOX2 Activity and Increasing Nrf2 Activity. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1195127
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1195127
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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