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Troxerutin Reduces Kidney Damage against BDE-47-Induced Apoptosis via Inhibiting NOX2 Activity and Increasing Nrf2 Activity
Joint Authors
Lu, Jun
Shan, Qun
Zheng, Yuanlin
Zhuang, Juan
Zheng, Guihong
Zhang, Zifeng
Zhang, Yanqiu
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-15
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
2,2,4,4-Tetrabromodiphenyl ether (BDE-47), one of the persistent organic pollutants, seriously influences the quality of life; however, its pathological mechanism remains unclear.
Troxerutin is a flavonoid with pharmacological activity of antioxidation and anti-inflammation.
In the present study, we investigated troxerutin against BDE-47-induced kidney cell apoptosis and explored the underlying mechanism.
The results show that troxerutin reduced renal cell apoptosis and urinary protein secretion in BDE-47-treated mice.
Western blot analysis shows that troxerutin supplement enhanced the ratio of Bcl-2/Bax; inhibited the release of cytochrome c from mitochondria, the activation of procaspase-9 and procaspase-3, and the cleavage of PARP; and reduced FAS, FASL, and caspase-8 levels induced by BDE-47.
In addition, troxerutin decreased the production of reactive oxygen species (ROS) and increased the activities of antioxidative enzymes.
Furthermore, troxerutin blunted Nrf2 ubiquitylation, enhanced the activity of Nrf2, decreased the activity of NOX2, and ameliorated kidney oxidant status of BDE-47-treated mice.
Together, these results confirm that troxerutin could alleviate the cytotoxicity of BDE-47 through antioxidation and antiapoptosis, which suggests that its protective mechanism is involved in the inhibition of apoptosis via suppressing NOX2 activity and increasing Nrf2 signaling pathway.
American Psychological Association (APA)
Shan, Qun& Zhuang, Juan& Zheng, Guihong& Zhang, Zifeng& Zhang, Yanqiu& Lu, Jun…[et al.]. 2017. Troxerutin Reduces Kidney Damage against BDE-47-Induced Apoptosis via Inhibiting NOX2 Activity and Increasing Nrf2 Activity. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1195127
Modern Language Association (MLA)
Shan, Qun…[et al.]. Troxerutin Reduces Kidney Damage against BDE-47-Induced Apoptosis via Inhibiting NOX2 Activity and Increasing Nrf2 Activity. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1195127
American Medical Association (AMA)
Shan, Qun& Zhuang, Juan& Zheng, Guihong& Zhang, Zifeng& Zhang, Yanqiu& Lu, Jun…[et al.]. Troxerutin Reduces Kidney Damage against BDE-47-Induced Apoptosis via Inhibiting NOX2 Activity and Increasing Nrf2 Activity. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1195127
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195127