Pomegranate Juice Prevents the Formation of Lung Nodules Secondary to Chronic Cigarette Smoke Exposure in an Animal Model
المؤلفون المشاركون
Husari, Ahmad
Hashem, Yasmine
Zaatari, Ghazi
El Sabban, Marwan
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-30
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Cigarette smoke (CS) induces an oxidative stress, DNA damage, and lung cancer.
Pomegranate juice (PJ) possess potent antioxidant activity attributed to its polyphenols.
We investigated whether PJ supplementation would prevent the formation of lung nodules, attenuate mitotic activity, and reduce hypoxia-inducible factor-1α (HIF-1α) expression secondary to CS exposure in an animal model.
Methods.
Mice were divided into: Control group, CS group, CS + PJ group, and PJ-only group.
CS and CS + PJ were exposed to CS, 5 days per week, for a total of 5 months.
Animals were then housed for additional four months.
CS + PJ and PJ groups received PJ throughout the experiment period while others received placebo.
At the end of the experiment, the incidence of lung nodules was assessed by (1) histological analysis, (2) mitotic activity [measurement of PHH3 antibodies], and (3) measurement of HIF-1α expression.
Results.
The incidence of lung nodules was significantly increased in CS.
CS exposure significantly increased PHH3 and HIF-1α expression.
PJ supplementation attenuated the formation of lung nodules and reduced PHH3 and HIF-1α expression.
Conclusion.
PJ supplementation significantly decreased the incidence of lung cancer, secondary to CS, prevented the formation of lung nodules, and reduced mitotic activity and HIF-1α expression in an animal model.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Husari, Ahmad& Hashem, Yasmine& Zaatari, Ghazi& El Sabban, Marwan. 2017. Pomegranate Juice Prevents the Formation of Lung Nodules Secondary to Chronic Cigarette Smoke Exposure in an Animal Model. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1195153
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Husari, Ahmad…[et al.]. Pomegranate Juice Prevents the Formation of Lung Nodules Secondary to Chronic Cigarette Smoke Exposure in an Animal Model. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1195153
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Husari, Ahmad& Hashem, Yasmine& Zaatari, Ghazi& El Sabban, Marwan. Pomegranate Juice Prevents the Formation of Lung Nodules Secondary to Chronic Cigarette Smoke Exposure in an Animal Model. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1195153
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1195153
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر