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Pomegranate Juice Prevents the Formation of Lung Nodules Secondary to Chronic Cigarette Smoke Exposure in an Animal Model
Joint Authors
Husari, Ahmad
Hashem, Yasmine
Zaatari, Ghazi
El Sabban, Marwan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Cigarette smoke (CS) induces an oxidative stress, DNA damage, and lung cancer.
Pomegranate juice (PJ) possess potent antioxidant activity attributed to its polyphenols.
We investigated whether PJ supplementation would prevent the formation of lung nodules, attenuate mitotic activity, and reduce hypoxia-inducible factor-1α (HIF-1α) expression secondary to CS exposure in an animal model.
Methods.
Mice were divided into: Control group, CS group, CS + PJ group, and PJ-only group.
CS and CS + PJ were exposed to CS, 5 days per week, for a total of 5 months.
Animals were then housed for additional four months.
CS + PJ and PJ groups received PJ throughout the experiment period while others received placebo.
At the end of the experiment, the incidence of lung nodules was assessed by (1) histological analysis, (2) mitotic activity [measurement of PHH3 antibodies], and (3) measurement of HIF-1α expression.
Results.
The incidence of lung nodules was significantly increased in CS.
CS exposure significantly increased PHH3 and HIF-1α expression.
PJ supplementation attenuated the formation of lung nodules and reduced PHH3 and HIF-1α expression.
Conclusion.
PJ supplementation significantly decreased the incidence of lung cancer, secondary to CS, prevented the formation of lung nodules, and reduced mitotic activity and HIF-1α expression in an animal model.
American Psychological Association (APA)
Husari, Ahmad& Hashem, Yasmine& Zaatari, Ghazi& El Sabban, Marwan. 2017. Pomegranate Juice Prevents the Formation of Lung Nodules Secondary to Chronic Cigarette Smoke Exposure in an Animal Model. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1195153
Modern Language Association (MLA)
Husari, Ahmad…[et al.]. Pomegranate Juice Prevents the Formation of Lung Nodules Secondary to Chronic Cigarette Smoke Exposure in an Animal Model. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1195153
American Medical Association (AMA)
Husari, Ahmad& Hashem, Yasmine& Zaatari, Ghazi& El Sabban, Marwan. Pomegranate Juice Prevents the Formation of Lung Nodules Secondary to Chronic Cigarette Smoke Exposure in an Animal Model. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1195153
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195153