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MNRR1, a Biorganellar Regulator of Mitochondria
المؤلفون المشاركون
Grossman, Lawrence I.
Purandare, Neeraja
Arshad, Rooshan
Gladyck, Stephanie
Somayajulu, Mallika
Hüttemann, Maik
Aras, Siddhesh
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-08
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The central role of energy metabolism in cellular activities is becoming widely recognized.
However, there are many gaps in our knowledge of the mechanisms by which mitochondria evaluate their status and call upon the nucleus to make adjustments.
Recently, a protein family consisting of twin CX9C proteins has been shown to play a role in human pathophysiology.
We focus here on two family members, the isoforms CHCHD2 (renamed MNRR1) and CHCHD10.
The better studied isoform, MNRR1, has the unusual property of functioning in both the mitochondria and the nucleus and of having a different function in each.
In the mitochondria, it functions by binding to cytochrome c oxidase (COX), which stimulates respiration.
Its binding to COX is promoted by tyrosine-99 phosphorylation, carried out by ABL2 kinase (ARG).
In the nucleus, MNRR1 binds to a novel promoter element in COX4I2 and itself, increasing transcription at 4% oxygen.
We discuss mutations in both MNRR1 and CHCHD10 found in a number of chronic, mostly neurodegenerative, diseases.
Finally, we propose a model of a graded response to hypoxic and oxidative stresses, mediated under different oxygen tensions by CHCHD10, MNRR1, and HIF1, which operate at intermediate and very low oxygen concentrations, respectively.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Grossman, Lawrence I.& Purandare, Neeraja& Arshad, Rooshan& Gladyck, Stephanie& Somayajulu, Mallika& Hüttemann, Maik…[et al.]. 2017. MNRR1, a Biorganellar Regulator of Mitochondria. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1195292
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Grossman, Lawrence I.…[et al.]. MNRR1, a Biorganellar Regulator of Mitochondria. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1195292
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Grossman, Lawrence I.& Purandare, Neeraja& Arshad, Rooshan& Gladyck, Stephanie& Somayajulu, Mallika& Hüttemann, Maik…[et al.]. MNRR1, a Biorganellar Regulator of Mitochondria. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1195292
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1195292
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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