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MNRR1, a Biorganellar Regulator of Mitochondria
Joint Authors
Grossman, Lawrence I.
Purandare, Neeraja
Arshad, Rooshan
Gladyck, Stephanie
Somayajulu, Mallika
Hüttemann, Maik
Aras, Siddhesh
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The central role of energy metabolism in cellular activities is becoming widely recognized.
However, there are many gaps in our knowledge of the mechanisms by which mitochondria evaluate their status and call upon the nucleus to make adjustments.
Recently, a protein family consisting of twin CX9C proteins has been shown to play a role in human pathophysiology.
We focus here on two family members, the isoforms CHCHD2 (renamed MNRR1) and CHCHD10.
The better studied isoform, MNRR1, has the unusual property of functioning in both the mitochondria and the nucleus and of having a different function in each.
In the mitochondria, it functions by binding to cytochrome c oxidase (COX), which stimulates respiration.
Its binding to COX is promoted by tyrosine-99 phosphorylation, carried out by ABL2 kinase (ARG).
In the nucleus, MNRR1 binds to a novel promoter element in COX4I2 and itself, increasing transcription at 4% oxygen.
We discuss mutations in both MNRR1 and CHCHD10 found in a number of chronic, mostly neurodegenerative, diseases.
Finally, we propose a model of a graded response to hypoxic and oxidative stresses, mediated under different oxygen tensions by CHCHD10, MNRR1, and HIF1, which operate at intermediate and very low oxygen concentrations, respectively.
American Psychological Association (APA)
Grossman, Lawrence I.& Purandare, Neeraja& Arshad, Rooshan& Gladyck, Stephanie& Somayajulu, Mallika& Hüttemann, Maik…[et al.]. 2017. MNRR1, a Biorganellar Regulator of Mitochondria. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1195292
Modern Language Association (MLA)
Grossman, Lawrence I.…[et al.]. MNRR1, a Biorganellar Regulator of Mitochondria. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1195292
American Medical Association (AMA)
Grossman, Lawrence I.& Purandare, Neeraja& Arshad, Rooshan& Gladyck, Stephanie& Somayajulu, Mallika& Hüttemann, Maik…[et al.]. MNRR1, a Biorganellar Regulator of Mitochondria. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1195292
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195292