The Involvement of Mg2+ in Regulation of Cellular and Mitochondrial Functions

الملخص EN

Mg2+ is an essential mineral with pleotropic impacts on cellular physiology and functions.

It acts as a cofactor of several important enzymes, as a regulator of ion channels such as voltage-dependent Ca2+ channels and K+ channels and on Ca2+-binding proteins.

In general, Mg2+ is considered as the main intracellular antagonist of Ca2+, which is an essential secondary messenger initiating or regulating a great number of cellular functions.

This review examines the effects of Mg2+ on mitochondrial functions with a particular focus on energy metabolism, mitochondrial Ca2+ handling, and apoptosis.