Are Antioxidants a Potential Therapy for FSHD? A Review of the Literature
المؤلفون المشاركون
Heather, Alison K.
Denny, Adam Philip
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-12
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Facioscapulohumeral muscular dystrophy (FSHD) is an inherited myopathy affecting approximately 1 in 7500 individuals worldwide.
It is a progressive disease characterised by skeletal muscle weakness and wasting.
A genetic mutation on the 4q35 chromosome results in the expression of the double homeobox 4 gene (DUX4) which drives oxidative stress, inflammation, toxicity, and atrophy within the skeletal muscle.
FSHD is characterised by oxidative stress, and there is currently no cure and a lack of therapies for the disease.
Antioxidants have been researched for many years, with investigators aiming to use antioxidants therapeutically for oxidative stress-associated diseases.
This has included both natural and synthetic antioxidants.
The use of antioxidants in preclinical or clinical models has been largely successful with a plethora of research reporting positive results.
However, when translated to clinical trials, the use of antioxidants as a therapeutic intervention for a variety of disease has been largely unsuccessful.
Moreover, specifically focusing on FSHD, limited research has been conducted on the use of antioxidants as a therapy in either preclinical or clinical models.
This review summarises the current state of antioxidant use in the treatment of FSHD and discusses their potential avenue for therapeutic use for FSHD patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Denny, Adam Philip& Heather, Alison K.. 2017. Are Antioxidants a Potential Therapy for FSHD? A Review of the Literature. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1195390
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Denny, Adam Philip& Heather, Alison K.. Are Antioxidants a Potential Therapy for FSHD? A Review of the Literature. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1195390
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Denny, Adam Philip& Heather, Alison K.. Are Antioxidants a Potential Therapy for FSHD? A Review of the Literature. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1195390
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1195390
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر