Are Antioxidants a Potential Therapy for FSHD? A Review of the Literature
Joint Authors
Heather, Alison K.
Denny, Adam Philip
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Facioscapulohumeral muscular dystrophy (FSHD) is an inherited myopathy affecting approximately 1 in 7500 individuals worldwide.
It is a progressive disease characterised by skeletal muscle weakness and wasting.
A genetic mutation on the 4q35 chromosome results in the expression of the double homeobox 4 gene (DUX4) which drives oxidative stress, inflammation, toxicity, and atrophy within the skeletal muscle.
FSHD is characterised by oxidative stress, and there is currently no cure and a lack of therapies for the disease.
Antioxidants have been researched for many years, with investigators aiming to use antioxidants therapeutically for oxidative stress-associated diseases.
This has included both natural and synthetic antioxidants.
The use of antioxidants in preclinical or clinical models has been largely successful with a plethora of research reporting positive results.
However, when translated to clinical trials, the use of antioxidants as a therapeutic intervention for a variety of disease has been largely unsuccessful.
Moreover, specifically focusing on FSHD, limited research has been conducted on the use of antioxidants as a therapy in either preclinical or clinical models.
This review summarises the current state of antioxidant use in the treatment of FSHD and discusses their potential avenue for therapeutic use for FSHD patients.
American Psychological Association (APA)
Denny, Adam Philip& Heather, Alison K.. 2017. Are Antioxidants a Potential Therapy for FSHD? A Review of the Literature. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1195390
Modern Language Association (MLA)
Denny, Adam Philip& Heather, Alison K.. Are Antioxidants a Potential Therapy for FSHD? A Review of the Literature. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1195390
American Medical Association (AMA)
Denny, Adam Philip& Heather, Alison K.. Are Antioxidants a Potential Therapy for FSHD? A Review of the Literature. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1195390
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195390