Protective Effects of Methane-Rich Saline on Rats with Lipopolysaccharide-Induced Acute Lung Injury
المؤلفون المشاركون
Ye, Xiaojian
Wang, WeiHeng
Sun, Aijun
Wang, Yang
Yang, Xiangqun
Ye, Zhouheng
Zhang, Chuansen
Sun, Xuejun
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-02
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Objective.
The aim of this research is to evaluate the protective effects of methane-rich saline (MS) on lipopolysaccharide- (LPS-) induced acute lung injury (ALI) and investigate its potential antioxidative, anti-inflammatory, and antiapoptotic activities.
Methods.
LPS-induced (20 mg/kg) ALI rats were injected with MS (2 ml/kg and 20 ml/kg) before the initiation of LPS induction.
Survival rate was determined until 96 h after LPS was induced.
Lung injury was assayed by oxygenation index, lung permeability index (LPI), wet-to-dry weight (W/D), and histology.
The cells in the bronchoalveolar lavage fluid (BALF) were counted.
Oxidative stress was examined by the level of malondialdehyde (MDA) and superoxide dismutase (SOD).
Inflammatory factors including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) in BALF were determined by ELISA.
Lung tissue apoptosis was detected by TUNEL staining and western blotting of caspase-3.
Results.
It was found that methane significantly prolonged the rat survival, decreased the lung W/D ratio and the content of the inflammatory factors, and reduced the amount of caspase-3 and apoptotic index.
In addition, MS increased the level of SOD and decreased the level of MDA significantly.
Conclusions.
MS protects the LPS-challenged ALI via antioxidative, anti-inflammatory, and antiapoptotic effect, which may prove to be a novel therapy for the clinical management of ALI.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sun, Aijun& Wang, WeiHeng& Ye, Xiaojian& Wang, Yang& Yang, Xiangqun& Ye, Zhouheng…[et al.]. 2017. Protective Effects of Methane-Rich Saline on Rats with Lipopolysaccharide-Induced Acute Lung Injury. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1195656
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sun, Aijun…[et al.]. Protective Effects of Methane-Rich Saline on Rats with Lipopolysaccharide-Induced Acute Lung Injury. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1195656
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sun, Aijun& Wang, WeiHeng& Ye, Xiaojian& Wang, Yang& Yang, Xiangqun& Ye, Zhouheng…[et al.]. Protective Effects of Methane-Rich Saline on Rats with Lipopolysaccharide-Induced Acute Lung Injury. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1195656
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1195656
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر