Curcumin-Loaded Mixed Micelles: Preparation, Characterization, and In Vitro Antitumor Activity

الملخص EN

The objective of this study was to prepare curcumin-loaded mixed Soluplus/TPGS micelles (Cur-TPGS-PMs) for oral administration.

The Cur-TPGS-PMs showed a mean size of 65.54 ± 2.57 nm, drug encapsulation efficiency over 85%, and drug loading of 8.17%.

The Cur-TPGS-PMs were found to be stable in various pH media (pH 1.2 for 2 h, pH 6.8 for 2 h, and pH 7.4 for 6 h).

The X-ray diffraction (XRD) patterns illustrated that curcumin was in the amorphous or molecular state within PMs.

The In vitro release test indicated that Cur-TPGS-PMs possessed a significant sustained-release property.

The cell viability in MCF-7 cells was found to be relatively lower in Cur-TPGS-PM-treated cells as compared to free Cur-treated cells.

CLSM imaging revealed that mixed micelles were efficiently absorbed into the cytoplasm region of MCF-7 cells.

Therefore, Cur-TPGS-PMs could have the significant value for the chronic breast cancer therapy.