Curcumin-Loaded Mixed Micelles: Preparation, Characterization, and In Vitro Antitumor Activity
Joint Authors
Zhao, Wenchang
Ji, Suping
Lin, Xiao
Yu, Enjiang
Dian, Chengyang
Yan, Xiong
Li, Liangyao
Zhang, Meimei
Dian, Linghui
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The objective of this study was to prepare curcumin-loaded mixed Soluplus/TPGS micelles (Cur-TPGS-PMs) for oral administration.
The Cur-TPGS-PMs showed a mean size of 65.54 ± 2.57 nm, drug encapsulation efficiency over 85%, and drug loading of 8.17%.
The Cur-TPGS-PMs were found to be stable in various pH media (pH 1.2 for 2 h, pH 6.8 for 2 h, and pH 7.4 for 6 h).
The X-ray diffraction (XRD) patterns illustrated that curcumin was in the amorphous or molecular state within PMs.
The In vitro release test indicated that Cur-TPGS-PMs possessed a significant sustained-release property.
The cell viability in MCF-7 cells was found to be relatively lower in Cur-TPGS-PM-treated cells as compared to free Cur-treated cells.
CLSM imaging revealed that mixed micelles were efficiently absorbed into the cytoplasm region of MCF-7 cells.
Therefore, Cur-TPGS-PMs could have the significant value for the chronic breast cancer therapy.
American Psychological Association (APA)
Ji, Suping& Lin, Xiao& Yu, Enjiang& Dian, Chengyang& Yan, Xiong& Li, Liangyao…[et al.]. 2018. Curcumin-Loaded Mixed Micelles: Preparation, Characterization, and In Vitro Antitumor Activity. Journal of Nanotechnology،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1195682
Modern Language Association (MLA)
Ji, Suping…[et al.]. Curcumin-Loaded Mixed Micelles: Preparation, Characterization, and In Vitro Antitumor Activity. Journal of Nanotechnology No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1195682
American Medical Association (AMA)
Ji, Suping& Lin, Xiao& Yu, Enjiang& Dian, Chengyang& Yan, Xiong& Li, Liangyao…[et al.]. Curcumin-Loaded Mixed Micelles: Preparation, Characterization, and In Vitro Antitumor Activity. Journal of Nanotechnology. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1195682
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195682