Acarbose Accelerates Wound Healing via AkteNOS Signaling in dbdb Mice
المؤلفون المشاركون
Han, Xue
Deng, Yaping
Yu, Jiawen
Sun, Yuannan
Ren, Guofei
Cai, Jian
Zhu, Jianjun
Jiang, Guojun
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-08
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Refractory wound is a dreaded complication of diabetes and is highly correlated with EPC dysfunction caused by hyperglycemia.
Acarbose is a widely used oral glucose-lowering drug exclusively for T2DM.
Previous studies have suggested the beneficial effect of acarbose on improving endothelial dysfunction in patients with T2DM.
However, no data have been reported on the beneficial efficacy of acarbose in wound healing impairment caused by diabetes.
We herein investigated whether acarbose could improve wound healing in T2DM db/db mice and the possible mechanisms involved.
Acarbose hastened wound healing and enhanced angiogenesis, accompanied by increased circulating EPC number in db/db mice.
In vitro, a reversed BM-EPC dysfunction was observed after the administration of acarbose in db/db mice, as reflected by tube formation assay.
In addition, a significantly increased NO production was also witnessed in BM-EPCs from acarbose treated db/db mice, with decreased O2 levels.
Akt inhibitor could abolish the beneficial effect of acarbose on high glucose induced EPC dysfunction in vitro, accompanied by reduced eNOS activation.
Acarbose displayed potential effect in promoting wound healing and improving angiogenesis in T2DM mice, which was possibly related to the Akt/eNOS signaling pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Han, Xue& Deng, Yaping& Yu, Jiawen& Sun, Yuannan& Ren, Guofei& Cai, Jian…[et al.]. 2017. Acarbose Accelerates Wound Healing via AkteNOS Signaling in dbdb Mice. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1195804
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Han, Xue…[et al.]. Acarbose Accelerates Wound Healing via AkteNOS Signaling in dbdb Mice. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1195804
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Han, Xue& Deng, Yaping& Yu, Jiawen& Sun, Yuannan& Ren, Guofei& Cai, Jian…[et al.]. Acarbose Accelerates Wound Healing via AkteNOS Signaling in dbdb Mice. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1195804
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1195804
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر