Acarbose Accelerates Wound Healing via AkteNOS Signaling in dbdb Mice
Joint Authors
Han, Xue
Deng, Yaping
Yu, Jiawen
Sun, Yuannan
Ren, Guofei
Cai, Jian
Zhu, Jianjun
Jiang, Guojun
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-08
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Refractory wound is a dreaded complication of diabetes and is highly correlated with EPC dysfunction caused by hyperglycemia.
Acarbose is a widely used oral glucose-lowering drug exclusively for T2DM.
Previous studies have suggested the beneficial effect of acarbose on improving endothelial dysfunction in patients with T2DM.
However, no data have been reported on the beneficial efficacy of acarbose in wound healing impairment caused by diabetes.
We herein investigated whether acarbose could improve wound healing in T2DM db/db mice and the possible mechanisms involved.
Acarbose hastened wound healing and enhanced angiogenesis, accompanied by increased circulating EPC number in db/db mice.
In vitro, a reversed BM-EPC dysfunction was observed after the administration of acarbose in db/db mice, as reflected by tube formation assay.
In addition, a significantly increased NO production was also witnessed in BM-EPCs from acarbose treated db/db mice, with decreased O2 levels.
Akt inhibitor could abolish the beneficial effect of acarbose on high glucose induced EPC dysfunction in vitro, accompanied by reduced eNOS activation.
Acarbose displayed potential effect in promoting wound healing and improving angiogenesis in T2DM mice, which was possibly related to the Akt/eNOS signaling pathway.
American Psychological Association (APA)
Han, Xue& Deng, Yaping& Yu, Jiawen& Sun, Yuannan& Ren, Guofei& Cai, Jian…[et al.]. 2017. Acarbose Accelerates Wound Healing via AkteNOS Signaling in dbdb Mice. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1195804
Modern Language Association (MLA)
Han, Xue…[et al.]. Acarbose Accelerates Wound Healing via AkteNOS Signaling in dbdb Mice. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1195804
American Medical Association (AMA)
Han, Xue& Deng, Yaping& Yu, Jiawen& Sun, Yuannan& Ren, Guofei& Cai, Jian…[et al.]. Acarbose Accelerates Wound Healing via AkteNOS Signaling in dbdb Mice. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1195804
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195804