Alleviation of Oxidative Damage and Involvement of Nrf2-ARE Pathway in Mesodopaminergic System and Hippocampus of Status Epilepticus Rats Pretreated by Intranasal Pentoxifylline
المؤلفون المشاركون
Kang, Yunxiao
Zhang, Guoliang
Cui, Huixian
Shi, Geming
Yan, Wensheng
Fang, Hui
Du, Yakun
Wang, Lei
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-12
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
The current studies were aimed at evaluating the efficacy of intranasal pentoxifylline (Ptx) pretreatment in protecting mesodopaminergic system and hippocampus from oxidative damage of lithium-pilocarpine induced status epilepticus (SE) and the involvement of nuclear factor erythroid 2-related factor 2- (Nrf2-) antioxidant response elements pathway.
Pentoxifylline was administered to rats intranasally or intraperitoneally 30 minutes before inducing SE.
Our results showed the impaired visuospatial memory, the defected mesodopaminergic system, and the oxidative damage and the transient activation of Nrf2 in SE rats.
The transient activation of Nrf2 in SE rats was enhanced by Ptx pretreatment, which was followed by the upregulation of heme oxygenase-1 and NAD(P)H:quinone oxidoreductase-1.
Ptx pretreatment to SE rats significantly suppressed the epileptic seizures, decreased the levels of lipid peroxide and malondialdehyde, and elevated the ratio of reduced glutathione/oxidized glutathione.
Compared with intraperitoneal injection, intranasal Ptx delivery completely restored the visuospatial memory and the activity of mesodopaminergic system in SE rats.
Intranasal administration of Ptx may hopefully become a noninvasive, painless, and easily administered option for epileptic patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kang, Yunxiao& Yan, Wensheng& Fang, Hui& Zhang, Guoliang& Du, Yakun& Shi, Geming…[et al.]. 2017. Alleviation of Oxidative Damage and Involvement of Nrf2-ARE Pathway in Mesodopaminergic System and Hippocampus of Status Epilepticus Rats Pretreated by Intranasal Pentoxifylline. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1195826
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shi, Geming…[et al.]. Alleviation of Oxidative Damage and Involvement of Nrf2-ARE Pathway in Mesodopaminergic System and Hippocampus of Status Epilepticus Rats Pretreated by Intranasal Pentoxifylline. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-18.
https://search.emarefa.net/detail/BIM-1195826
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kang, Yunxiao& Yan, Wensheng& Fang, Hui& Zhang, Guoliang& Du, Yakun& Shi, Geming…[et al.]. Alleviation of Oxidative Damage and Involvement of Nrf2-ARE Pathway in Mesodopaminergic System and Hippocampus of Status Epilepticus Rats Pretreated by Intranasal Pentoxifylline. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1195826
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1195826
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر