Alleviation of Oxidative Damage and Involvement of Nrf2-ARE Pathway in Mesodopaminergic System and Hippocampus of Status Epilepticus Rats Pretreated by Intranasal Pentoxifylline
Joint Authors
Kang, Yunxiao
Zhang, Guoliang
Cui, Huixian
Shi, Geming
Yan, Wensheng
Fang, Hui
Du, Yakun
Wang, Lei
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-12
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
The current studies were aimed at evaluating the efficacy of intranasal pentoxifylline (Ptx) pretreatment in protecting mesodopaminergic system and hippocampus from oxidative damage of lithium-pilocarpine induced status epilepticus (SE) and the involvement of nuclear factor erythroid 2-related factor 2- (Nrf2-) antioxidant response elements pathway.
Pentoxifylline was administered to rats intranasally or intraperitoneally 30 minutes before inducing SE.
Our results showed the impaired visuospatial memory, the defected mesodopaminergic system, and the oxidative damage and the transient activation of Nrf2 in SE rats.
The transient activation of Nrf2 in SE rats was enhanced by Ptx pretreatment, which was followed by the upregulation of heme oxygenase-1 and NAD(P)H:quinone oxidoreductase-1.
Ptx pretreatment to SE rats significantly suppressed the epileptic seizures, decreased the levels of lipid peroxide and malondialdehyde, and elevated the ratio of reduced glutathione/oxidized glutathione.
Compared with intraperitoneal injection, intranasal Ptx delivery completely restored the visuospatial memory and the activity of mesodopaminergic system in SE rats.
Intranasal administration of Ptx may hopefully become a noninvasive, painless, and easily administered option for epileptic patients.
American Psychological Association (APA)
Kang, Yunxiao& Yan, Wensheng& Fang, Hui& Zhang, Guoliang& Du, Yakun& Shi, Geming…[et al.]. 2017. Alleviation of Oxidative Damage and Involvement of Nrf2-ARE Pathway in Mesodopaminergic System and Hippocampus of Status Epilepticus Rats Pretreated by Intranasal Pentoxifylline. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1195826
Modern Language Association (MLA)
Shi, Geming…[et al.]. Alleviation of Oxidative Damage and Involvement of Nrf2-ARE Pathway in Mesodopaminergic System and Hippocampus of Status Epilepticus Rats Pretreated by Intranasal Pentoxifylline. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-18.
https://search.emarefa.net/detail/BIM-1195826
American Medical Association (AMA)
Kang, Yunxiao& Yan, Wensheng& Fang, Hui& Zhang, Guoliang& Du, Yakun& Shi, Geming…[et al.]. Alleviation of Oxidative Damage and Involvement of Nrf2-ARE Pathway in Mesodopaminergic System and Hippocampus of Status Epilepticus Rats Pretreated by Intranasal Pentoxifylline. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1195826
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195826