Differential Expression of Prostaglandin I2 Synthase Associated with Arachidonic Acid Pathway in the Oral Squamous Cell Carcinoma
المؤلفون المشاركون
Goloni-Bertollo, Eny Maria
Pavarino, Érika Cristina
Russo, Anelise
Biselli-Chicote, Patrícia M.
Kawasaki-Oyama, Rosa S.
Castanhole-Nunes, Márcia M. U.
Maniglia, José V.
Santi Neto, Dalísio de
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-08
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Introduction.
Differential expression of genes encoding cytochrome P450 (CYP) and other oxygenases enzymes involved in biotransformation mechanisms of endogenous and exogenous compounds can lead to oral tumor development.
Objective.
We aimed to identify the expression profile of these genes, searching for susceptibility biomarkers in oral squamous cell carcinoma.
Patients and Methods.
Sixteen oral squamous cell carcinoma samples were included in this study (eight tumor and eight adjacent non-tumor tissues).
Gene expression quantification was performed using TaqMan Array Human CYP450 and other Oxygenases 96-well plate (Applied Biosystems) by real time qPCR.
Protein quantification was performed by ELISA and IHC methods.
Bioinformatics tools were used to find metabolic pathways related to the enzymes encoded by differentially expressed genes.
Results.
CYP27B1, CYP27A1, CYP2E1, CYP2R1, CYP2J2, CYP2U1, CYP4F12, CYP4X1, CYP4B1, PTGIS, ALOX12, and MAOB genes presented differential expression in the oral tumors.
After correction by multiple tests, only the PTGIS (Prostaglandin I2 Synthase) gene presented significant differential expression (P < 0.05).
The PTGIS gene and protein were reduced in oral tumors.
Conclusion.
PTGIS presents downexpression in oral tumors.
PTGIS play an important role in the arachidonic acid metabolism.
Arachidonic acid and/or metabolites are derived from this pathway, which can influence the regulation of important physiological mechanisms in tumorigenesis process.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Russo, Anelise& Biselli-Chicote, Patrícia M.& Kawasaki-Oyama, Rosa S.& Castanhole-Nunes, Márcia M. U.& Maniglia, José V.& Santi Neto, Dalísio de…[et al.]. 2018. Differential Expression of Prostaglandin I2 Synthase Associated with Arachidonic Acid Pathway in the Oral Squamous Cell Carcinoma. Journal of Oncology،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1195830
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Russo, Anelise…[et al.]. Differential Expression of Prostaglandin I2 Synthase Associated with Arachidonic Acid Pathway in the Oral Squamous Cell Carcinoma. Journal of Oncology No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1195830
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Russo, Anelise& Biselli-Chicote, Patrícia M.& Kawasaki-Oyama, Rosa S.& Castanhole-Nunes, Márcia M. U.& Maniglia, José V.& Santi Neto, Dalísio de…[et al.]. Differential Expression of Prostaglandin I2 Synthase Associated with Arachidonic Acid Pathway in the Oral Squamous Cell Carcinoma. Journal of Oncology. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1195830
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1195830
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر