Aging: Molecular Pathways and Implications on the Cardiovascular System

المؤلفون المشاركون

Medeiros, Isac Almeida de
Ribeiro, Thais P.
Almeida, Arthur José Pontes Oliveira de

المصدر

Oxidative Medicine and Cellular Longevity

العدد

المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-19، 19ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2017-08-09

دولة النشر

مصر

عدد الصفحات

19

التخصصات الرئيسية

الأحياء

الملخص EN

The world’s population over 60 years is growing rapidly, reaching 22% of the global population in the next decades.

Despite the increase in global longevity, individual healthspan needs to follow this growth.

Several diseases have their prevalence increased by age, such as cardiovascular diseases, the leading cause of morbidity and mortality worldwide.

Understanding the aging biology mechanisms is fundamental to the pursuit of cardiovascular health.

In this way, aging is characterized by a gradual decline in physiological functions, involving the increased number in senescent cells into the body.

Several pathways lead to senescence, including oxidative stress and persistent inflammation, as well as energy failure such as mitochondrial dysfunction and deregulated autophagy, being ROS, AMPK, SIRTs, mTOR, IGF-1, and p53 key regulators of the metabolic control, connecting aging to the pathways which drive towards diseases.

In addition, senescence can be induced by cellular replication, which resulted from telomere shortening.

Taken together, it is possible to draw a common pathway unifying aging to cardiovascular diseases, and the central point of this process, senescence, can be the target for new therapies, which may result in the healthspan matching the lifespan.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Almeida, Arthur José Pontes Oliveira de& Ribeiro, Thais P.& Medeiros, Isac Almeida de. 2017. Aging: Molecular Pathways and Implications on the Cardiovascular System. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-19.
https://search.emarefa.net/detail/BIM-1195836

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Almeida, Arthur José Pontes Oliveira de…[et al.]. Aging: Molecular Pathways and Implications on the Cardiovascular System. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-19.
https://search.emarefa.net/detail/BIM-1195836

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Almeida, Arthur José Pontes Oliveira de& Ribeiro, Thais P.& Medeiros, Isac Almeida de. Aging: Molecular Pathways and Implications on the Cardiovascular System. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-19.
https://search.emarefa.net/detail/BIM-1195836

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1195836