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Aging: Molecular Pathways and Implications on the Cardiovascular System
Joint Authors
Medeiros, Isac Almeida de
Ribeiro, Thais P.
Almeida, Arthur José Pontes Oliveira de
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-09
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
The world’s population over 60 years is growing rapidly, reaching 22% of the global population in the next decades.
Despite the increase in global longevity, individual healthspan needs to follow this growth.
Several diseases have their prevalence increased by age, such as cardiovascular diseases, the leading cause of morbidity and mortality worldwide.
Understanding the aging biology mechanisms is fundamental to the pursuit of cardiovascular health.
In this way, aging is characterized by a gradual decline in physiological functions, involving the increased number in senescent cells into the body.
Several pathways lead to senescence, including oxidative stress and persistent inflammation, as well as energy failure such as mitochondrial dysfunction and deregulated autophagy, being ROS, AMPK, SIRTs, mTOR, IGF-1, and p53 key regulators of the metabolic control, connecting aging to the pathways which drive towards diseases.
In addition, senescence can be induced by cellular replication, which resulted from telomere shortening.
Taken together, it is possible to draw a common pathway unifying aging to cardiovascular diseases, and the central point of this process, senescence, can be the target for new therapies, which may result in the healthspan matching the lifespan.
American Psychological Association (APA)
Almeida, Arthur José Pontes Oliveira de& Ribeiro, Thais P.& Medeiros, Isac Almeida de. 2017. Aging: Molecular Pathways and Implications on the Cardiovascular System. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-19.
https://search.emarefa.net/detail/BIM-1195836
Modern Language Association (MLA)
Almeida, Arthur José Pontes Oliveira de…[et al.]. Aging: Molecular Pathways and Implications on the Cardiovascular System. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-19.
https://search.emarefa.net/detail/BIM-1195836
American Medical Association (AMA)
Almeida, Arthur José Pontes Oliveira de& Ribeiro, Thais P.& Medeiros, Isac Almeida de. Aging: Molecular Pathways and Implications on the Cardiovascular System. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-19.
https://search.emarefa.net/detail/BIM-1195836
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195836