Effect of Bioactive Compound of Aronia melanocarpa on Cardiovascular System in Experimental Hypertension
المؤلفون المشاركون
Pecháňová, Olga
Cebova, Martina
Klimentova, Jana
Janega, Pavol
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-30
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Aronia melanocarpa has attracted scientific interest due to its dense contents of different polyphenols.
We aimed to analyse effects of Aronia melanocarpa (AME) extract on blood pressure (BP), lipid peroxidation, cytokine level, total NOS activity in the left ventricle (LV), and aorta of L-NAME-induced hypertensive rats.
12-week-old male WKY rats were assigned to the control group and groups treated with AME extract (57.90 mg/kg/day), L-NAME (40 mg/kg/day), or combination of L-NAME (40 mg/kg/day) and AME (57.90 mg/kg/day) in tap water for 3 weeks.
NOS activity, eNOS protein expression, and conjugated diene (CD) concentration were determined in the LV and aorta.
After 3 weeks of L-NAME treatment, BP was increased by 28% and concomitant treatment with AME reduced it by 21%.
NOS activity of the LV and aorta in the L-NAME group was decreased by about 40%, while AME increased it almost on the control level.
AME-induced eNOS upregulation may contribute to increase NOS activity.
Moreover, AME decreased CD concentration in the LV and aorta and TNF-α and IL-6 production in the plasma were increased by L-NAME treatment.
In conclusion, our results showed that active substances of Aronia melanocarpa may have a positive effect on blood pressure, NOS activity, and proinflammatory processes in L-NAME-induced hypertension.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cebova, Martina& Klimentova, Jana& Janega, Pavol& Pecháňová, Olga. 2017. Effect of Bioactive Compound of Aronia melanocarpa on Cardiovascular System in Experimental Hypertension. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1195941
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cebova, Martina…[et al.]. Effect of Bioactive Compound of Aronia melanocarpa on Cardiovascular System in Experimental Hypertension. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1195941
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cebova, Martina& Klimentova, Jana& Janega, Pavol& Pecháňová, Olga. Effect of Bioactive Compound of Aronia melanocarpa on Cardiovascular System in Experimental Hypertension. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1195941
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1195941
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر