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Effect of Bioactive Compound of Aronia melanocarpa on Cardiovascular System in Experimental Hypertension
Joint Authors
Pecháňová, Olga
Cebova, Martina
Klimentova, Jana
Janega, Pavol
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aronia melanocarpa has attracted scientific interest due to its dense contents of different polyphenols.
We aimed to analyse effects of Aronia melanocarpa (AME) extract on blood pressure (BP), lipid peroxidation, cytokine level, total NOS activity in the left ventricle (LV), and aorta of L-NAME-induced hypertensive rats.
12-week-old male WKY rats were assigned to the control group and groups treated with AME extract (57.90 mg/kg/day), L-NAME (40 mg/kg/day), or combination of L-NAME (40 mg/kg/day) and AME (57.90 mg/kg/day) in tap water for 3 weeks.
NOS activity, eNOS protein expression, and conjugated diene (CD) concentration were determined in the LV and aorta.
After 3 weeks of L-NAME treatment, BP was increased by 28% and concomitant treatment with AME reduced it by 21%.
NOS activity of the LV and aorta in the L-NAME group was decreased by about 40%, while AME increased it almost on the control level.
AME-induced eNOS upregulation may contribute to increase NOS activity.
Moreover, AME decreased CD concentration in the LV and aorta and TNF-α and IL-6 production in the plasma were increased by L-NAME treatment.
In conclusion, our results showed that active substances of Aronia melanocarpa may have a positive effect on blood pressure, NOS activity, and proinflammatory processes in L-NAME-induced hypertension.
American Psychological Association (APA)
Cebova, Martina& Klimentova, Jana& Janega, Pavol& Pecháňová, Olga. 2017. Effect of Bioactive Compound of Aronia melanocarpa on Cardiovascular System in Experimental Hypertension. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1195941
Modern Language Association (MLA)
Cebova, Martina…[et al.]. Effect of Bioactive Compound of Aronia melanocarpa on Cardiovascular System in Experimental Hypertension. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1195941
American Medical Association (AMA)
Cebova, Martina& Klimentova, Jana& Janega, Pavol& Pecháňová, Olga. Effect of Bioactive Compound of Aronia melanocarpa on Cardiovascular System in Experimental Hypertension. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1195941
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195941