Salvianolic Acid Exerts Cardioprotection through Promoting Angiogenesis in Animal Models of Acute Myocardial Infarction: Preclinical Evidence
المؤلفون المشاركون
Thapa, Saroj
Chu, Maoping
Zheng, Qun
Bao, Xiao-Yi
Yu, Long-jie
Zhang, Ke-Jian
Zhu, Jia-Zhen
Wang, Yan
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-21
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Radix Salviae miltiorrhizae, danshen root (danshen), is one of the widely used Chinese herbal medicines in clinics, containing rich phenolic compounds.
Salvianolic acid is the main active compound responsible for the pharmacologic effects of danshen.
Here, we aimed to evaluate the effects of salvianolic acid on cardioprotection through promoting angiogenesis in experimental myocardial infarction.
Studies of salvianolic acid in animal models of myocardial infarction were obtained from 6 databases until April 2016.
The outcome measures were vascular endothelium growth factor (VEGF), blood vessel density (BVD), and myocardial infarct size.
All the data were analyzed using Rev-Man 5.3 software.
Ultimately, 14 studies were identified involving 226 animals.
The quality score of studies ranged from 3 to 6.
The meta-analysis of six studies showed significant effects of salvianolic acid on increasing VEGF expression compared with the control group (P<0.01).
The meta-analysis of the two salvianolic acid A studies and three salvianolic acid B studies showed significantly improving BVD compared with the control group (P<0.01).
The meta-analysis of five studies showed significant effects of salvianolic acid for decreasing myocardial infarct size compared with the control group (P<0.01).
In conclusion, these findings demonstrated that salvianolic acid can exert cardioprotection through promoting angiogenesis in animal models of myocardial infarction.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yu, Long-jie& Zhang, Ke-Jian& Zhu, Jia-Zhen& Zheng, Qun& Bao, Xiao-Yi& Thapa, Saroj…[et al.]. 2017. Salvianolic Acid Exerts Cardioprotection through Promoting Angiogenesis in Animal Models of Acute Myocardial Infarction: Preclinical Evidence. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1195952
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yu, Long-jie…[et al.]. Salvianolic Acid Exerts Cardioprotection through Promoting Angiogenesis in Animal Models of Acute Myocardial Infarction: Preclinical Evidence. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1195952
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yu, Long-jie& Zhang, Ke-Jian& Zhu, Jia-Zhen& Zheng, Qun& Bao, Xiao-Yi& Thapa, Saroj…[et al.]. Salvianolic Acid Exerts Cardioprotection through Promoting Angiogenesis in Animal Models of Acute Myocardial Infarction: Preclinical Evidence. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1195952
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1195952
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر