Salvianolic Acid Exerts Cardioprotection through Promoting Angiogenesis in Animal Models of Acute Myocardial Infarction: Preclinical Evidence
Joint Authors
Thapa, Saroj
Chu, Maoping
Zheng, Qun
Bao, Xiao-Yi
Yu, Long-jie
Zhang, Ke-Jian
Zhu, Jia-Zhen
Wang, Yan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-21
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Radix Salviae miltiorrhizae, danshen root (danshen), is one of the widely used Chinese herbal medicines in clinics, containing rich phenolic compounds.
Salvianolic acid is the main active compound responsible for the pharmacologic effects of danshen.
Here, we aimed to evaluate the effects of salvianolic acid on cardioprotection through promoting angiogenesis in experimental myocardial infarction.
Studies of salvianolic acid in animal models of myocardial infarction were obtained from 6 databases until April 2016.
The outcome measures were vascular endothelium growth factor (VEGF), blood vessel density (BVD), and myocardial infarct size.
All the data were analyzed using Rev-Man 5.3 software.
Ultimately, 14 studies were identified involving 226 animals.
The quality score of studies ranged from 3 to 6.
The meta-analysis of six studies showed significant effects of salvianolic acid on increasing VEGF expression compared with the control group (P<0.01).
The meta-analysis of the two salvianolic acid A studies and three salvianolic acid B studies showed significantly improving BVD compared with the control group (P<0.01).
The meta-analysis of five studies showed significant effects of salvianolic acid for decreasing myocardial infarct size compared with the control group (P<0.01).
In conclusion, these findings demonstrated that salvianolic acid can exert cardioprotection through promoting angiogenesis in animal models of myocardial infarction.
American Psychological Association (APA)
Yu, Long-jie& Zhang, Ke-Jian& Zhu, Jia-Zhen& Zheng, Qun& Bao, Xiao-Yi& Thapa, Saroj…[et al.]. 2017. Salvianolic Acid Exerts Cardioprotection through Promoting Angiogenesis in Animal Models of Acute Myocardial Infarction: Preclinical Evidence. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1195952
Modern Language Association (MLA)
Yu, Long-jie…[et al.]. Salvianolic Acid Exerts Cardioprotection through Promoting Angiogenesis in Animal Models of Acute Myocardial Infarction: Preclinical Evidence. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1195952
American Medical Association (AMA)
Yu, Long-jie& Zhang, Ke-Jian& Zhu, Jia-Zhen& Zheng, Qun& Bao, Xiao-Yi& Thapa, Saroj…[et al.]. Salvianolic Acid Exerts Cardioprotection through Promoting Angiogenesis in Animal Models of Acute Myocardial Infarction: Preclinical Evidence. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1195952
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195952