Modulatory Effect of Fermented Papaya Extracts on Mammary Gland Hyperplasia Induced by Estrogen and Progestin in Female Rats
المؤلفون المشاركون
You, Zhenqiang
Sun, Junying
Xie, Feng
Chen, Zhiqin
Zhang, Sheng
Chen, Hao
Liu, Fang
Li, Lili
Chen, Guocan
Song, Yisheng
Xuan, Yaoxian
Zheng, Gaoli
Xin, Yanfei
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-20
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Fermented papaya extracts (FPEs) are obtained by fermentation of papaya by Aspergillus oryzae and yeasts.
In this study, we investigated the protective effects of FPEs on mammary gland hyperplasia induced by estrogen and progestogen.
Rats were randomly divided into 6 groups, including a control group, an FPE-alone group, a model group, and three FPE treatment groups (each receiving 30, 15, or 5 ml/kg FPEs).
Severe mammary gland hyperplasia was induced upon estradiol benzoate and progestin administration.
FPEs could improve the pathological features of the animal model and reduce estrogen levels in the serum.
Analysis of oxidant indices revealed that FPEs could increase superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities, decrease malondialdehyde (MDA) level in the mammary glands and serum of the animal models, and decrease the proportion of cells positive for the oxidative DNA damage marker 8-oxo-dG in the mammary glands.
Additionally, estradiol benzoate and progestin altered the levels of serum biochemical compounds such as aspartate transaminase (AST), total bilirubin (TBIL), and alanine transaminase (ALT), as well as hepatic oxidant indices such as SOD, GSH-Px, MDA, and 8-oxo-2′-deoxyguanosine (8-oxo-dG).
These indices reverted to normal levels upon oral administration of a high dose of FPEs.
Taken together, our results indicate that FPEs can protect the mammary glands and other visceral organs from oxidative damage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
You, Zhenqiang& Sun, Junying& Xie, Feng& Chen, Zhiqin& Zhang, Sheng& Chen, Hao…[et al.]. 2017. Modulatory Effect of Fermented Papaya Extracts on Mammary Gland Hyperplasia Induced by Estrogen and Progestin in Female Rats. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1195963
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
You, Zhenqiang…[et al.]. Modulatory Effect of Fermented Papaya Extracts on Mammary Gland Hyperplasia Induced by Estrogen and Progestin in Female Rats. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1195963
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
You, Zhenqiang& Sun, Junying& Xie, Feng& Chen, Zhiqin& Zhang, Sheng& Chen, Hao…[et al.]. Modulatory Effect of Fermented Papaya Extracts on Mammary Gland Hyperplasia Induced by Estrogen and Progestin in Female Rats. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1195963
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1195963
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر