Modulatory Effect of Fermented Papaya Extracts on Mammary Gland Hyperplasia Induced by Estrogen and Progestin in Female Rats
Joint Authors
You, Zhenqiang
Sun, Junying
Xie, Feng
Chen, Zhiqin
Zhang, Sheng
Chen, Hao
Liu, Fang
Li, Lili
Chen, Guocan
Song, Yisheng
Xuan, Yaoxian
Zheng, Gaoli
Xin, Yanfei
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Fermented papaya extracts (FPEs) are obtained by fermentation of papaya by Aspergillus oryzae and yeasts.
In this study, we investigated the protective effects of FPEs on mammary gland hyperplasia induced by estrogen and progestogen.
Rats were randomly divided into 6 groups, including a control group, an FPE-alone group, a model group, and three FPE treatment groups (each receiving 30, 15, or 5 ml/kg FPEs).
Severe mammary gland hyperplasia was induced upon estradiol benzoate and progestin administration.
FPEs could improve the pathological features of the animal model and reduce estrogen levels in the serum.
Analysis of oxidant indices revealed that FPEs could increase superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities, decrease malondialdehyde (MDA) level in the mammary glands and serum of the animal models, and decrease the proportion of cells positive for the oxidative DNA damage marker 8-oxo-dG in the mammary glands.
Additionally, estradiol benzoate and progestin altered the levels of serum biochemical compounds such as aspartate transaminase (AST), total bilirubin (TBIL), and alanine transaminase (ALT), as well as hepatic oxidant indices such as SOD, GSH-Px, MDA, and 8-oxo-2′-deoxyguanosine (8-oxo-dG).
These indices reverted to normal levels upon oral administration of a high dose of FPEs.
Taken together, our results indicate that FPEs can protect the mammary glands and other visceral organs from oxidative damage.
American Psychological Association (APA)
You, Zhenqiang& Sun, Junying& Xie, Feng& Chen, Zhiqin& Zhang, Sheng& Chen, Hao…[et al.]. 2017. Modulatory Effect of Fermented Papaya Extracts on Mammary Gland Hyperplasia Induced by Estrogen and Progestin in Female Rats. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1195963
Modern Language Association (MLA)
You, Zhenqiang…[et al.]. Modulatory Effect of Fermented Papaya Extracts on Mammary Gland Hyperplasia Induced by Estrogen and Progestin in Female Rats. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1195963
American Medical Association (AMA)
You, Zhenqiang& Sun, Junying& Xie, Feng& Chen, Zhiqin& Zhang, Sheng& Chen, Hao…[et al.]. Modulatory Effect of Fermented Papaya Extracts on Mammary Gland Hyperplasia Induced by Estrogen and Progestin in Female Rats. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1195963
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195963